Glycosylated hemoglobin is associated with systemic inflammation, hypercoagulability, and prognosis of COVID-19 patients
Glycosylated hemoglobin is associated with systemic inflammation, hypercoagulability, and prognosis of COVID-19 patients
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DOI：
10.1016/j.diabres.2020.108214
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发表时间：
2020-06-01
影响因子：
5.1
通讯作者：
Zhu, Fengxue
中科院分区：
文献类型：
--
作者：
Wang, Zhenzhou;Du, Zhe;Zhu, Fengxue
背景糖尿病是冠状病毒病（COVID-19）进展和预后的危险因素，但糖化血红蛋白（HbA 1c）水平、炎症和COVID-19患者预后之间的关系尚未探讨。收集并分析他们的人口统计学数据、病史、COVID-19的体征和症状、实验室检查结果以及COVID-19治疗的最终结果。三组患者SaO 2、血清铁蛋白、C反应蛋白、血沉、纤维蛋白原、IL 6水平差异有统计学意义。两两比较，B组、C组CRP、ESR、Fbg、IL 6、血清铁蛋白水平与A组比较差异有统计学意义（P < 0.05）。相关分析显示SaO 2与HbA 1c呈直线负相关（r =-0.22，P = 0.01），而血清铁蛋白、CRP、Fbg和ESR水平与HbA 1c之间呈线性正相关结论高HbA 1c水平与COVID-19患者的炎症、高凝状态和低SaO 2相关，糖尿病患者死亡率较高（27.7%）。因此，入院后测定HbA 1c水平有助于评估COVID-19患者的炎症、高凝状态和预后。
BackgroundDiabetes is a risk factor for the progression and prognosis of coronavirus disease (COVID-19), but the relationship between glycosylated hemoglobin (HbA1c) level, inflammation, and prognosis of COVID-19 patients has not been explored.MethodsThis was a retrospective study of COVID-19 patients who underwent an HbA1c test. Their demographic data, medical history, signs and symptoms of COVID-19, laboratory test results, and final outcomes of COVID-19 treatment were collected and analyzed.ResultsA total of 132 patients were included and divided into three groups based on their blood glucose status. There were significant differences in SaO2, serum ferritin level, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen (Fbg) level, and IL6 level among the three groups. A pairwise comparison of the groups showed that groups B and C were significantly different from group A in terms of CRP, ESR, and Fbg, IL6, and serum ferritin levels (P < 0.05). Correlation analysis showed that there was a linear negative correlation between SaO2and HbA1c (r = −0.22, P = 0.01), while there was a linear positive correlation between serum ferritin, CRP, Fbg, and ESR levels and HbA1c (P < 0.05).ConclusionsHigh HbA1c level is associated with inflammation, hypercoagulability, and low SaO2in COVID-19 patients, and the mortality rate (27.7%) is higher in patients with diabetes. Determining HbA1c level after hospital admission is thus helpful assessing inflammation, hypercoagulability, and prognosis of COVID-19 patients.