Two Novel Antibiotic Resistance Genes, tet(44) and ant(6)-Ib, Are Located within a Transferable Pathogenicity Island in Campylobacter fetus subsp fetus
Two Novel Antibiotic Resistance Genes, tet(44) and ant(6)-Ib, Are Located within a Transferable Pathogenicity Island in Campylobacter fetus subsp fetus
复制标题
DOI：
10.1128/aac.00304-10
复制
发表时间：
2010-07-01
影响因子：
4.9
通讯作者：
Perreten, Vincent
中科院分区：
文献类型：
--
作者：
Abril, Carlos;Brodard, Isabelle;Perreten, Vincent
在胎儿弯曲杆菌中发现了新的四环素和链霉素耐药基因泰特（44）和ant（6）-Ib。胎儿内的可转移的致病性岛，通常是独特的胎儿弯曲杆菌亚种。venerealis。由640个氨基酸组成的四环素抗性决定簇泰特44属于一类通过核糖体保护赋予四环素和米诺环素抗性的蛋白质。由286个氨基酸组成的链霉素抗性决定簇ANT（6）-Ib属于氨基糖苷类核苷酸转移酶家族。通过基因失活和表达鉴定抗性表型。
New tetracycline and streptomycin resistance genes, tet(44) and ant(6)-Ib, were identified in Campylobacter fetus subsp. fetus within a transferable pathogenicity island that is typically unique to Campylobacter fetus subsp. venerealis. The 640-amino-acid tetracycline resistance determinant, Tet 44, belongs to a class of proteins that confers resistance to tetracycline and minocycline by ribosomal protection. The 286-amino-acid streptomycin resistance determinant, ANT(6)-Ib, belongs to a family of aminoglycoside nucleotidyltransferases. The resistance phenotypes were demonstrated by gene inactivation and expression.