Immunosurveillance and immunotherapy of tumors by innate immune cells.
Immunosurveillance and immunotherapy of tumors by innate immune cells.
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DOI：
10.1016/j.coi.2015.11.001
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发表时间：
2016-02
影响因子：
7
通讯作者：
Raulet DH
中科院分区：
文献类型：
--
作者：
Iannello A;Thompson TW;Ardolino M;Marcus A;Raulet DH
越来越多的证据支持先天免疫效应细胞在肿瘤监视中的作用。自然杀伤（NK）细胞和骨髓细胞代表先天免疫细胞的两个主要亚群，其具有有效但完全不同的肿瘤抑制能力。在这里，我们描述了生殖细胞编码的NK细胞受体，在抑制肿瘤的发展中发挥作用，并简要描述了导致其配体在肿瘤细胞中上调的细胞途径。我们还描述了巨噬细胞消除肿瘤细胞的潜在机制，以及最近表征的致力于感测与抗肿瘤免疫反应有关的胞质DNA的机制。
Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing efficient but quite different tumor suppressive abilities. Here, we describe the germline-encoded NK cell receptors that play a role in suppressing tumor development and describe briefly the cellular pathways leading to the upregulation of their ligands in tumor cells. We also describe mechanisms underlying the elimination of tumor cells by macrophages and a recently characterized mechanism dedicated to sensing cytosolic DNA that is implicated in anti-tumor immune responses.