Synthetic studies relevant to biosynthetic research on vitamin B12. Part 2. Syntheses of C-methylated chlorins via lactams
Synthetic studies relevant to biosynthetic research on vitamin B12. Part 2. Syntheses of C-methylated chlorins via lactams
复制标题
与维生素 B12 生物合成研究相关的合成研究。
DOI：
--
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
R. Snow
中科院分区：
文献类型：
--
作者：
A. Battersby;C. Fookes;R. Snow
C-甲基化氯素的合成有两种方法。首先，最终氯的环-B和环-C被顺序地构建在硫代内酰胺体系上，该体系充当A-D组分。优选的替代方法包括将作为A-D前体的内酰胺(二氢吡咯甲酮)与作为B-C组分的吡咯甲烷连接在一起，最后在CuII模板上对氯进行封环。
C-Methylated chlorins have been synthesised by two approaches. For one, ring-B and ring-C of the final chlorin were built sequentially onto a thiolactam system which acted as the A-D component. The preferred alternative method involved joining together a lactam (a dihydropyrromethenone) as A-D precursor with a pyrromethane as the B-C component, the final ring-closure to the chlorin being carried out on a CuII template.