DEVELOPMENTAL VARIATION IN WHOLE HUMAN LUNG PHOSPHATIDYLCHOLINE MOLECULAR-SPECIES - A COMPARISON WITH GUINEA-PIG AND RAT
DEVELOPMENTAL VARIATION IN WHOLE HUMAN LUNG PHOSPHATIDYLCHOLINE MOLECULAR-SPECIES - A COMPARISON WITH GUINEA-PIG AND RAT
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DOI：
10.1016/0378-3782(91)90112-g
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发表时间：
1991-06-01
影响因子：
2.5
通讯作者：
POSTLE, AD
中科院分区：
文献类型：
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作者：
HUNT, AN;KELLY, FJ;POSTLE, AD
对胎儿发育期间人类和啮齿动物肺磷脂酰胆碱 (PC) 种类模式的详细分析表明，两种双饱和种类逐渐增加。 在每个时间点，二棕榈酰 PC (PC16:0/16:0) 和肉豆蔻酰棕榈酰 PC (PC14:0/16:0) 分数含量的上升伴随着棕榈酰油酰 PC (PC16:0/18:1) 类似幅度的下降。 高达 20% 的足月肺 PC 为 PC14:0/16:0。 啮齿类动物肺 PC 饱和度的暂时增加在妊娠期比人类晚开始，而大鼠中 PC 饱和度的显着增加仅发生在出生后。 在这方面，豚鼠与人类更为相似。 对于每只哺乳动物，全肺 PC16:0/16:0 与 PC16:0/18:1 的比率（P/O 比率）提供了胎儿肺成熟度的敏感标志。 人类、豚鼠和大鼠的整个成人肺的 PC 组成及其在支气管肺泡灌洗样品中的饱和富集度相似。 我们认为豚鼠为人类肺早产研究提供了一个有用的模型。
Detailed analysis of the pattern of human and rodent lung phosphatidylcholine (PC) species during fetal development revealed a progressive increase in two disaturated species. The rise in the fractional content of dipalmitoyl PC (PC16:0/16:0) and myristoylpalmitoyl PC (PC14:0/16:0) was accompanied at each time point by a fall of similar magnitude in palmitoyloleoyl PC (PC16:0/18:1). Up to 20% of term lung PC was PC14:0/16:0. The temporal increase in rodent lung PC saturation began later in gestation than the human, and in the rat a significant increase in PC saturation only occurred postnatally. In this respect the guinea pig more closely resembled the human. For each mammal, a ratio of whole lung PC16:0/16:0 to PC16:0/18:1 (the P/O ratio) provided a sensitive marker of fetal lung maturity. The PC composition of whole adult lung and its saturation enrichment in bronchoalveolar lavage samples were similar in human, guinea pig and rat. We propose that the guinea pig provides a useful model for human lung prematurity studies.