Acoustic cavitation in phacoemulsification: Chemical effects, modes of action and cavitation index
Acoustic cavitation in phacoemulsification: Chemical effects, modes of action and cavitation index
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DOI：
10.1016/s0301-5629(02)00514-8
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发表时间：
2002-06-01
影响因子：
2.9
通讯作者：
Gedankeni, A
中科院分区：
文献类型：
--
作者：
Topaz, M;Motiei, M;Gedankeni, A
在过去的30年中，高强度超声（US）能量（HIUE）已广泛用于各种外科手术，包括超声乳化术。产生的自由基和声致发光（SL）的应用程序的连续波（CW）HIVE模拟白内障超声乳化手术的条件下的水介质中证明了电子顺磁共振（EPR）光谱和灵敏的光子检测系统。研究结果为模拟眼内环境中声空化的产生提供了直接证据，指出超声在临床超声乳化和其他手术应用中产生声空化是可能的。研究结果表明，在水介质中的声空化效应可能有助于超声乳化白内障手术后临床观察到的内皮损伤。灌注溶液与各种气体的饱和改变了声空化。灌注溶液的CO饱和，实际上消除了声空化，同时消除了自由基和SonL。在超声乳化和其他医学应用中，临床上可利用CO（2）抑制声空化。引入空化指数（CI）用于标准化超声乳化仪器和采用HIDE的其他US医疗器械。（电子邮件：topazmd@netvision.net.il）（C）2002年世界医学生物学超声联合会。
High-intensity ultrasound (US) energy (HIUE) has been extensively used in the last 3 decades in a wide range of surgical procedures, including phacoemulsification. The generation of radicals and sonoluminescence (SL) by application of continuous-wave (CW) HIVE to an aqueous medium under conditions simulating cataract phacoemulsification surgery is demonstrated by electron paramagnetic resonance (EPR) spectroscopy and a sensitive photon-detecting system. The findings provide direct evidence for the generation of acoustic cavitation in the simulated intraocular environment, pointing out that generation of acoustic cavitation in clinical phacoemulsification and other surgical applications of US is possible. The findings imply that the effects of acoustic cavitation in aqueous medium may contribute to the endothelial damage observed clinically following phacoemulsification cataract surgery. Saturation of the irrigating solution with various gases modifies the acoustic cavitation. Saturation of the irrigating solution with CO, practically eliminates acoustic cavitation, with the concomitant elimination of radicals and SonL. CO(2) may be utilized clinically to suppress acoustic cavitation in phacoemulsification and other medical applications. A cavitation index (CI) is introduced for the purpose of standardizing phacoemulsification instrumentation and other medical US devices that employ HIDE. (E-mail: topazmd@netvision.net.il) (C) 2002 World Federation for Ultrasound in Medicine Biology.