microRNA in erythrocytes
microRNA in erythrocytes
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DOI：
10.1042/bst0380229
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发表时间：
2010-02-01
影响因子：
3.9
通讯作者：
Hamilton, Andrew J.
中科院分区：
文献类型：
--
作者：
Hamilton, Andrew J.
人们普遍认为哺乳动物红细胞缺乏RNA，因此无法响应内部或外部信号翻译新蛋白质。对这一长期观点的支持来自各种研究，其中大多数都集中在 RNA 的总含量或翻译的整体水平上。然而，最近对特定类型 RNA 的研究表明，人类红细胞中同时存在 Y RNA 和 microRNA。后者似乎特别不协调，因为它们的正常作用是减弱 mRNA 的翻译。 Y RNA 结合 Ro 自身抗原，可能在细胞 RNA 质量控制中发挥作用。因此，这两种非编码 RNA 的存在表明红细胞中可能存在其他隐性 RNA。它还表明这些细胞中存在低水平的翻译或涉及 microRNA 的新的未表征的过程。
Mammalian erythrocytes are generally thought to lack RNA and therefore to be unable to translate new proteins in response to internal or external signals. Support for this long-standing view has accumulated from diverse studies, most of which have focused on the total content of RNA or the overall level of translation. However, more recent work on specific types of RNA has shown the presence in human erythrocytes of both Y RNA and microRNA. The latter seem particularly incongruous given that their normal role is to attenuate the translation of mRNA. Y RNA binds the Ro autoantigen which may have a role in cellular RNA quality control. Therefore the presence of both of these non-coding RNAs indicates the possible existence of other cryptic RNAs in erythrocytes. it also suggests either the existence of low levels of translation or new uncharacterized processes involving microRNA in these cells.