Expression and characterization of c‐Myb in prenatal odontogenesis
Expression and characterization of c‐Myb in prenatal odontogenesis
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c-Myb 在产前牙发育中的表达和特征
DOI：
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
J. Šmarda
中科院分区：
文献类型：
--
作者：
E. Matalova;M. Buchtová;A. Tucker;T. Bender;E. Janečková;Vlasta Lungova;S. Balková;J. Šmarda
转录因子c-Myb参与细胞增殖、存活和分化的控制。由于这些过程伴随着牙齿发育的形态发生，这项工作研究了c-Myb在牙齿发育过程中的可能作用。在单齿型小鼠中分析c-Myb的表达之后，在双齿型物种（猪）中进行了类似的分析，猪的齿系更接近于人类。c-Myb的分布与增殖和凋亡的模式相关，还评估了c-Myb突变小鼠的牙齿表型。在小鼠中，在第一磨牙的整个产前发育过程中检测到c-Myb表达。c-Myb表达与细胞凋亡呈负相关，与细胞增殖呈正相关。然而，c-Myb阳性细胞比增殖细胞核抗原阳性细胞更丰富，表明c-Myb在牙齿发生中的其他作用。在小型猪中，与小鼠相反，c-Myb阳性细胞呈不对称排列，在牙胚和牙板的唇侧存在较多。在靠近牙芽的间充质中有一簇阴性细胞。在后期，阳性细胞的数量减少，这些细胞位于牙乳头的上部，在未来的牙尖形成的区域。c-Myb在两个物种中的成牙本质细胞和成釉细胞中的表达在牙本质和釉质产生阶段都很强，这表明c-Myb在牙齿矿化过程中可能具有新的作用。
The transcription factor c‐Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c‐Myb during odontogenesis. Analysis of the expression of c‐Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c‐Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c‐Myb mutant mice was also assessed. In the mouse, c‐Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c‐Myb expression and apoptosis, while c‐Myb expression positively correlated with proliferation. c‐Myb‐positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c‐Myb in odontogenesis. In the minipig, in contrast to the mouse, there was an asymmetrical arrangement of c‐Myb positive cells, with a higher presence on the labial side of the tooth germ and dental lamina. A cluster of negative cells was situated in the mesenchyme close to the tooth bud. At later stages, the number of positive cells decreased and these cells were situated in the upper part of the dental papilla in the areas of future cusp formation. The expression of c‐Myb in both species was strong in the odontoblasts and ameloblasts at the stage of dentin and enamel production suggesting a possible novel role of c‐Myb during tooth mineralization.
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鼠 A-myb：差异剪接和组织特异性表达的证据。
影响因子：
8
作者：
Mettus,RV;Litvin,J;Wali,A;Toscani,A;Latham,K;Hatton,K;Reddy,EP
通讯作者：
Reddy,EP
DOI：
10.1387/ijdb.7848830
发表时间：
1994-09
期刊：
The International journal of developmental biology
影响因子：
--
作者：
J. Jernvall;P. Kettunen;I. Karavanova;L. Martin;Irma Thesleff
通讯作者：
J. Jernvall;P. Kettunen;I. Karavanova;L. Martin;Irma Thesleff
DOI：
10.1016/j.bbagrm.2008.08.013
发表时间：
2009-02
影响因子：
4.7
作者：
Perez-Casellas, Laura A.;Wang, Xiaoying;Howard, Kristy D.;Rehage, Mark W.;Strong, Donna D.;Linkhart, Thomas A.
通讯作者：
Linkhart, Thomas A.
DOI：
10.1006/bbrc.2001.4307
发表时间：
2001-02-16
影响因子：
3.1
作者：
Falany, ML;Thames, AM;Williams, JP
通讯作者：
Williams, JP