Limitations of FDG-PET and FDG-PET with computed tomography for detecting synchronous cancer in pharyngeal cancer.
Limitations of FDG-PET and FDG-PET with computed tomography for detecting synchronous cancer in pharyngeal cancer.
复制标题
FDG-PET 和 FDG-PET 联合计算机断层扫描检测咽癌同步癌的局限性。
DOI：
10.1001/archotol.134.11.1191
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
M. Nishio
中科院分区：
文献类型：
--
作者：
Hidenori Suzuki;Y. Hasegawa;A. Terada;T. Ogawa;I. Hyodo;Masahiro Suzuki;T. Nakashima;Tsuneo Tamaki;M. Nishio
目的
分析18氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）及其与计算机断层扫描（FDG-PET/CT）的融合技术对咽部鳞状细胞癌（SCC）合并上消化道癌的诊断价值。同时上消化道癌是治疗咽部鳞状细胞癌的一个重要问题，特别是对于据报道处于高风险的日本人群。据报道，FDG-PET和FDG-PET/CT在头颈部鳞状细胞癌（HNSCC）分期中的应用效果良好。另一个优点是，这两种技术预计将证明在检测同步癌症有用。
设计
回顾性分析病历。
设置
爱知癌症中心，名古屋，日本。
患者
通过与UGI Lugol染色内镜比较，评估了43例日本咽部SCC患者的FDG-PET和FDG-PET/CT检测同步UGI癌的能力。患者在治疗前接受了17次FDG-PET和26次FDG-PET/CT扫描。
主要观察指标
FDG-PET和FDG-PET/CT检测同步UGI癌的灵敏度。
结果
病理学上，6例食管鳞状细胞癌（14%）和4例胃腺癌（9%）诊断的基础上可疑病变的UGI卢戈染色内镜检测。FDG-PET/CT发现1例患者患有T2期食管癌，但无患者患有UGI癌。FDG-PET和FDG-PET/CT诊断T1 UGI癌的敏感性为0%。
结论
诊断技术的选择必须基于同步肿瘤的部位和组织学特征。虽然FDG-PET和FDG-PET/CT仍然是HNSCC分期的首选技术，但在高危人群中，两者都不能取代Lugol染色内镜检测同步UGI癌。
OBJECTIVE
To analyze the ability of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and the fusion of FDG-PET with computed tomography (FDG-PET/CT) to detect synchronous upper gastrointestinal tract (UGI) cancer in newly diagnosed pharyngeal squamous cell carcinoma (SCC). Synchronous UGI cancer is a significant problem in treating pharyngeal SCC, particularly for Japanese populations reported to be at high risk. Good results have been reported from the use of FDG-PET and FDG-PET/CT in staging head and neck SCC (HNSCC). An additional advantage is that both techniques are expected to prove useful in detecting synchronous cancer.
DESIGN
Retrospective analysis of medical records.
SETTING
Aichi Cancer Center, Nagoya, Japan.
PATIENTS
Forty-three Japanese patients with pharyngeal SCC were assessed for the ability of FDG-PET and FDG-PET/CT to detect synchronous UGI cancer via a comparison with UGI Lugol chromoendoscopy. The patients had undergone 17 FDG-PET and 26 FDG-PET/CT scans before treatment.
MAIN OUTCOME MEASURE
Sensitivity of FDG-PET and FDG-PET/CT to detect synchronous UGI cancer.
RESULTS
Pathologically, 6 patients with esophageal SCC (14%) and 4 with stomach adenocarcinoma (9%) were diagnosed on the basis of suspect lesions detected by UGI Lugol chromoendoscopy. One patient was found to have stage T2 esophageal cancer by FDG-PET/CT, but no patients had UGI cancer. The sensitivity of detecting T1 UGI cancer by FDG-PET and FDG-PET/CT was 0%.
CONCLUSIONS
The choice of diagnostic technique must be based on the site and histologic characteristics of the synchronous tumor. Although FDG-PET and FDG-PET/CT are still the preferred techniques for staging HNSCC, neither replaces Lugol chromoendoscopy for detecting synchronous UGI cancer in high-risk populations.
影响因子：
4.7
作者：
Muto, M;Takahashi, M;Esumi, H
通讯作者：
Esumi, H