Current insights into the role of transforming growth factor-β in bone resorption
Current insights into the role of transforming growth factor-β in bone resorption
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DOI：
10.1016/j.mce.2005.09.008
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发表时间：
2005-11-24
影响因子：
4.1
通讯作者：
Lovibond, AC
中科院分区：
文献类型：
--
作者：
Fox, SW;Lovibond, AC
转化生长因子-P (TGF-β) 对细胞增殖和分化产生多种影响。 TGF-β的主要储存库是骨骼，它对破骨细胞分化和骨吸收具有单独的促进和抑制作用。如果没有 TGF-β 的直接刺激，单核细胞无法形成破骨细胞，而是遵循巨噬细胞分化途径。这种促进作用取决于促进前体抵抗抗破骨细胞炎症信号的状态的能力。吸收开始后，TGF-β从骨基质中释放。它作用于成骨细胞，减少破骨细胞分化因子 RANKL（NF kappa B 配体的受体激活剂）的可用性，从而间接限制破骨细胞的进一步形成。因此，TGF-β在骨吸收的控制中具有基本作用，其作用首先使单核细胞发育成破骨细胞，然后在其从骨基质释放后限制骨吸收的程度和持续时间。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Transforming growth factor-P (TGF-beta) elicits a variety of effects on cellular proliferation and differentiation. The major repository for TGF-beta is bone, where it possesses separate facilitative and suppressive actions on osteoclast differentiation and bone resorption. Without a direct enabling stimulus from TGF-beta monocytes cannot form osteoclasts but instead follow macrophage differentiation pathways. This facilitative action depends on an ability to promote a state in which precursors are resistant to anti-osteoclastic inflammatory signals. Following the initiation of resorption TGF-beta is released from bone matrix. This acts on osteoblasts to reduce the availability of the osteoclast differentiation factor, RANKL (receptor activator of NF kappa B ligand) and thereby indirectly limits further osteoclast formation. Thus TGF-beta has a fundamental role in the control of bone resorption having actions that first allow monocytes to develop into osteoclasts then subsequently limiting the extent and duration of resorption after its release from the bone matrix. (c) 2005 Elsevier Ireland Ltd. All rights reserved.