Seasonality of tuberculosis.
Seasonality of tuberculosis.
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DOI：
10.4103/0974-777x.77296
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发表时间：
2011-01
影响因子：
1.6
通讯作者：
Fares A
中科院分区：
文献类型：
--
作者：
Fares A
本研究旨在回顾以往的研究，并分析与结核病（TB）季节性变异相关的当前知识和争议，以探讨结核病是否具有年度季节性模式。使用属于 PubMed 和 Cochrane 图书馆的在线数据库，以关键词“结核病，季节性影响”和“结核病，季节性变异”对通过文献检索确定的同行评审研究进行系统回顾。搜索仅限于以英文发表的文章。还审查了已确定论文的进一步相关出版物的参考文献。对 1971 年至 2006 年间在世界 11 个国家/地区（喀麦隆西南部、南非、印度、香港、日本、科威特、西班牙、英国、爱尔兰、俄罗斯和蒙古）进行的 12 项研究进行了审查。所有国家（喀麦隆西南部和俄罗斯除外）都在春季和夏季出现结核病的季节性模式，主要高峰期。对季节性的观察导致我们假设结核分枝杆菌的传播风险似乎在冬季最大。维生素 D 水平变异、室内活动、免疫功能的季节性变化以及结核病诊断和治疗的延迟是季节性结核病的潜在刺激因素。此外，食物供应和食物摄入量的季节性变化、年龄和性别也是影响结核病通知变异性的重要因素。强烈建议对此主题和其他相关主题进行前瞻性研究。
This study was designed to review previous studies and analyse the current knowledge and controversies related to seasonal variability of tuberculosis (TB) to examine whether TB has an annual seasonal pattern. Systematic review of peer reviewed studies identified through literature searches using online databases belonging to PubMed and the Cochrane library with key words “Tuberculosis, Seasonal influence” and “Tuberculosis, Seasonal variation”. The search was restricted to articles published in English. The references of the identified papers for further relevant publications were also reviewed. Twelve studies conducted between the period 1971 and 2006 from 11 countries/regions around the world (South Western Cameroon, South Africa, India, Hong Kong, Japan, Kuwait, Spain, UK, Ireland, Russia, and Mongolia) were reviewed. A seasonal pattern of tuberculosis with a mostly predominant peak is seen during the spring and summer seasons in all of the countries (except South Western Cameroon and Russia). The observation of seasonality leads to assume that the risk of transmission of M. tuberculosis does appear to be the greatest during winter months. Vitamin D level variability, indoor activities, seasonal change in immune function, and delays in the diagnosis and treatment of tuberculosis are potential stimuli of seasonal tuberculosis disease. Additionally, seasonal variation in food availability and food intake, age, and sex are important factors which can play a role in the tuberculosis notification variability. Prospective studies regarding this topic and other related subjects are highly recommended.