DIABETIC NEUROPATHY AND THE MICROCIRCULATION
DIABETIC NEUROPATHY AND THE MICROCIRCULATION
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DOI：
10.1111/j.1464-5491.1995.tb00480.x
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发表时间：
1995-04-01
影响因子：
3.5
通讯作者：
TOOKE, JE
中科院分区：
文献类型：
--
作者：
FLYNN, MD;TOOKE, JE
糖尿病微循环异常与糖尿病神经病变有密切关系。神经源性因素在微循环的调节中起着重要作用。在糖尿病神经病变中，这些机制的损伤导致严重的血液动力学紊乱，动静脉分流增加，血流的异常姿势调节和对组织损伤的异常炎症反应。微血管血流动力学的异常神经源性调节可能有助于微血管病变的发展，表现为基底增厚增加，两者无疑都与糖尿病足溃疡的发病机制有关。反过来，现在认识到，微血管异常可能有助于糖尿病神经病变的缺血性病因。
There is a close relationship between the abnormal microcirculation in diabetic subjects and diabetic neuropathy. Neurogenic factors play a prominent role in the regulation of the microcirculation. In diabetic neuropathy, damage to these mechanisms results in a profound haemodynamic disturbance with increased arteriovenous shunting, abnormal postural regulation of blood flow, and abnormal inflammatory responses to tissue injury. Abnormal neurogenic regulation of microvascular haemodynamics may contribute to the development of microangiopathy manifest as increased basement thickening and both are undoubtedly implicated in the pathogenesis of diabetic foot ulceration. In turn it is now recognized that microvascular abnormalities may contribute to the ischaemic aetiology of diabetic neuropathy.