Bone marrow chimerism and transplantation tolerance.
Bone marrow chimerism and transplantation tolerance.
复制标题
骨髓嵌合和移植耐受。
DOI：
10.1016/s0952-7915(97)80042-8
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发表时间：
1997
影响因子：
7
通讯作者：
Sykes,M
中科院分区：
文献类型：
--
作者：
Nikolic,B;Sykes,M
将同种或异种多能造血干细胞植入非骨髓清除但免疫耗竭（预处理）的受者中可产生对供体和宿主的免疫耐受状态。进入胸腺的宿主和供体造血细胞确保了供体和宿主反应性胸腺细胞的缺失。在未免疫耗竭的受体中诱导的耐受涉及其他机制。将供体胸腺组织移植到胸腺切除的受体是诱导中心T细胞耐受而不需要移植供体造血干细胞的替代方法。在过去的一年中，在了解预处理的要求和上述移植模型中诱导耐受的机制方面取得了进展。
Engraftment of allogeneic or xenogeneic pluripotent hematopoietic stem cells into nonmyeloablated but immunodepleted (preconditioned) recipients can produce a state of immunological tolerance to donor and host. Host and donor hematopoietic cells entering the thymus ensure deletion of both donor- and host-reactive thymocytes. Additional mechanisms are involved in tolerance induced in recipients that are not immunodepleted. Grafting of donor thymic tissue to thymectomized recipients is an alternative approach for inducing central T cell tolerance without the requirement for engraftment of donor hematopoietic stem cells. During the past year, advances have been made in understanding both the requirements for preconditioning and the mechanisms of tolerance induction in the above transplantation models.