Apolipoprotein synthesis in nonalcoholic steatohepatitis
Apolipoprotein synthesis in nonalcoholic steatohepatitis
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DOI：
10.1053/jhep.2002.32527
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发表时间：
2002-04-01
期刊：
影响因子：
13.5
通讯作者：
Nair, KS
中科院分区：
文献类型：
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作者：
Charlton, N;Sreekumar, R;Nair, KS
肝脂肪变性是非酒精性脂肪性肝病的先决条件，其病理生理机制尚不清楚。由于极低密度脂蛋白（VLDL）的形成是肝脏脂质输出的主要途径，我们假设apoB-100的合成，在肝脏VLDL形成的速率决定步骤，可能会改变非酒精性脂肪性肝炎（NASH）患者。本研究评价了NASH患者和无NASH的瘦和体重指数（BMI）匹配（肥胖）对照组中载脂蛋白B-100（apo B-100）的相对合成率。使用预充的L-[1-C-13]亮氨酸连续输注来测量7名NASH患者的apoB-100和纤维蛋白原的绝对合成率（ASR），并将其与7名瘦型和7名肥胖（BMI匹配）的非NASH对照进行比较。测定纤维蛋白原和白蛋白的ASR。NASH患者apoB-100的平均ASR（31.5 ± 3.4 mg/kg/d）低于肥胖患者（115.2 ± 7.2 mg/kg/d，P
The pathophysiology of hepatic steatosis, a prerequisite of nonalcoholic fatty liver disease, is poorly understood. Because very-low-density lipoprotein (VLDL) formation is the chief route of hepatic lipid export, we hypothesized that the synthesis of apoB-100, a rate-determining step in hepatic VLDL formation, may be altered in patients with nonalcoholic steatohepatitis (NASH). This study evaluated the relative synthesis rates of apolipoprotein B-100 (apoB-100) in patients with NASH and in lean and body mass index (BMI)-matched (Obese) controls without NASH. A primed continuous infusion of L-[1-C-13] leucine was used to measure the absolute synthesis rates (ASR) of apoB-100 and fibrinogen in 7 patients with NASH and compared them with 7 lean and 7 obese (BMI-matched) controls without NASH. The ASRs of fibrinogen and albumin also were measured. The mean ASR of apoB-100 in patients with NASH was lower (31.5 +/- 3.4 mg/kg/d) than that of obese (115.2 +/- 7.2 mg/kg/d, P