Genetic Predictors of Susceptibility to Dermatophytoses
Genetic Predictors of Susceptibility to Dermatophytoses
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DOI：
10.1007/s11046-016-0046-z
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发表时间：
2017-02-01
期刊：
影响因子：
5.5
通讯作者：
Abdel-Rahman, Susan M.
中科院分区：
文献类型：
--
作者：
Abdel-Rahman, Susan M.
上个世纪进行的无数观察性研究表明，皮肤癣菌感染各种年龄、种族、性别和社会经济地位的人的比率非常高。在人群内部和人群之间观察到的皮肤真菌感染模式的奇怪差异导致无数研究人员探索是否遗传学是皮肤真菌感染的易感性基础，还是赋予保护作用。本文研究了提供遗传学和皮肤植物病之间的联系的数据，并讨论了支持这些观察的潜在机制。
Countless observational studies conducted over the last century reveal that dermatophytes infect humans of every age, race, gender, and socioeconomic status with strikingly high rates. The curious disparity in dermatophyte infection patterns observed within and between populations has led countless investigators to explore whether genetics underlie a susceptibility to, or confer protection against, dermatophyte infections. This paper examines the data that offer a link between genetics and dermatophytoses and discusses the underlying mechanisms that support these observations.