Current concepts on the theories of the mechanism of action of fluoride
Current concepts on the theories of the mechanism of action of fluoride
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DOI：
10.1080/000163599428562
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发表时间：
1999-12-01
影响因子：
2
通讯作者：
ten Cate, JM
中科院分区：
文献类型：
--
作者：
ten Cate, JM
烟道涂层的防龋性主要归因于其对牙齿口腔液界面脱矿化/再矿化的影响。唾液中低于ppm的氟化物水平有效地将脱矿、导致龋齿的平衡转移到再矿化。这是由于氟化物促进了磷酸钙的沉淀，并在牙齿组织中形成了氟羟基磷灰石。低氟；用含氟牙膏刷牙后，唾液中的氟化物含量较低。类似的浓度在干扰细菌的生长和新陈代谢过程中没有效果，也不会因为(牢固结合的)氟化物的掺入而导致牙齿矿物的溶解显著减少。对氟化物功效的比较研究表明，在牙本质的pH-C保持研究中，溶液中的浓度比牙釉质中的浓度更高，以维持矿物质平衡或诱导再矿化。这是因为与牙釉质相比，牙本质的溶解度更高，牙本质晶体的尺寸更小。氟化物缓释装置以氟化物释放修复材料的形式，可能有助于将唾液和牙菌斑中的氟化物水平提高到可以预防龋齿的水平，对高危患者也是如此。氟治疗后的滞留与缓释、氟化物与抗微生物治疗的结合、个体化防治等是今后千年的研究问题和未来氟应用的展望。将预防方案与龋病诊断的新进展结合起来。
The caries-preventive effect of flue ride is mainly attributed to the effects on demineralization/remineralization at dic tooth oral fluids interface. Sub ppm levels of fluoride in saliva are effective in shifting the balance from demineralization, leading to caries, to remineralization. This is attributed to the fluoride-enhanced precipitation of calcium phosphates, and the formation of fluorhydroxyapatite in the dental tissues. Low; fluoride levels are found in saliva after toothbrushing with fluoride containing dentifrices. Similar concentrations are ineffective in interfering with processes of growth and metabolism of bacteria, and also do nor result ill a significantly reduced dissolution of tooth mineral as a result of (firmly bound) fluoride incorporation. Comparative studies of fluoride efficacy have shown that higher concentrations in solution are needed in pH-c) cling studies of dentine than in enamel to maintain the mineral balance or to induce remineralization. This is attributed to the greater solubility of the dentine and the smaller size of the dentine crystallites compared to enamel. Fluoride slow-release devices, in the form of fluoride-releasing restorative materials, may serve to increase the fluoride levels in saliva and plaque to levels at which caries can be prevented, also in high-risk patient. Research questions for the next millennium and Future perspectives for fluoride applications should be found in the retention and slow release of fluoride after various combinations of fluoride treatment, the combination of fluoride and anti-microbial treatment, the individualization of cal ies prevention. and the combination of preventive schemes with new developments in caries diagnosis.