Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat
Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat
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DOI：
10.1016/j.peptides.2004.03.004
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发表时间：
2004-06-01
期刊：
影响因子：
3
通讯作者：
Ueta, Y
中科院分区：
文献类型：
--
作者：
Jun, SA;Yumi, O;Ueta, Y
我们检测了6周龄和18周龄雄性肥胖大鼠弓状核（ARC）和垂体后叶（PP）中甘丙肽样肽（GALP）基因的表达。GALP mRNA在ARC中的BRA大鼠显着下降，在6和18周龄和GALP mRNA在PP中的BRA大鼠显着增加，在18周龄相比，瘦Fal？大鼠高血糖大鼠的胰岛素治疗部分逆转了这些变化。这些结果表明，GALP基因的表达在大鼠的瘦素不依赖的机制可能部分调节。(C)2004年爱思唯尔公司All rights reserved.
We examined the galanin-like peptide (GALP) gene expression in the arcuate nucleus (ARC) and posterior pituitary (PP) in 6- and 18-week-old male obese falfa rats. GALP mRNA in the ARC in falfa rats was significantly decreased in 6- and 18-week-old and GALP mRNA in the PP in falfa rats was significantly increased in 18-week-old compared to lean Fal? rats. Insulin treatment in hyperglycemic falfa rats partially reversed those changes. These results suggest that the GALP gene expression in falfa rats might be regulated in part by leptin-independent mechanisms. (C) 2004 Elsevier Inc. All rights reserved.