Serum C-reactive protein as an important prognostic variable in patients with diffuse large B cell lymphoma
Serum C-reactive protein as an important prognostic variable in patients with diffuse large B cell lymphoma
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DOI：
10.1007/s13277-012-0337-z
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发表时间：
2012-08-01
期刊：
影响因子：
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通讯作者：
Jiang, Wen-qi
中科院分区：
文献类型：
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作者：
Cao, Ye;Shi, Yan-xia;Jiang, Wen-qi
C-反应蛋白(CRP)是一种急性期反应物，在多种癌症患者中是一种很有前途的生物标志物。这项回顾性研究的目的是评估CRP水平的显著变化作为评估弥漫性大B细胞淋巴瘤(DLBCL)患者疗效和长期生存的参数。收集2006年10月至2009年8月在中山大学肿瘤防治中心就诊的94例DLBCL患者的血清CRP水平。结果与临床资料相关联。DLBCL患者血清CRP值男性为30.91+/-53.35，女性为22.39+/-29.89 mg/L。基线C反应蛋白水平与国际预后指数(IPI)评分相关(p=0.03)。在IPI评分为1-2的患者中，基线C反应蛋白水平与长期生存相关(p=0.001)。基线C反应蛋白水平与OS呈正相关(p=0.001.0 5)，且随临床分期的不同而不同(p=0.0 3)。化疗2个周期的患者C反应蛋白水平与近期疗效(P=0.003.0 1)、OS(P=0.0 4)或TTP(P=0.0 3)相关。血清CRP水平可作为弥漫性大B细胞型淋巴瘤患者的附加预后指标。
C-reactive protein (CRP) is an acute-phase reactant that is a promising biomarker in patients with cancer of many kinds. The aim of this retrospective study was to evaluate significant changes in CRP levels as a parameter for the response effect and long-term survival of patients with diffuse large B cell lymphoma (DLBCL). Serum CRP data were collected in 94 patients with DLBCL from October 2006 to August 2009 in Cancer Center, Sun Yat-Sen University. Results were correlated with clinical data. The median CRP serum level in patients with DLBCL was 30.91 +/- 53.35 in male and 22.39 +/- 29.89 mg/L in female. Base line CRP levels were correlated with International Prognostic Index (IPI) scores (p = 0.03). Among the patients with an IPI score of 1-2, base line CRP levels were correlated with long-term survival (p = 0.001). Base line CRP levels were also correlated with OS (p = 0.001) and varied with different clinical stages (p = 0.03). The corresponding CRP levels in the patients with 2 cycles of chemotherapy were correlated with short-term treatment response (p = 0.003) and OS (p = 0.04) or TTP (p = 0.03). CRP serum levels can be used as additional prognostic parameter in patients with diffuse large B cell type lymphoma.