People who survive an episode of severe alcoholic hepatitis should be advised to maintain total abstinence from alcohol
People who survive an episode of severe alcoholic hepatitis should be advised to maintain total abstinence from alcohol
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应建议在严重酒精性肝炎发作后幸存的人保持完全戒酒
DOI：
10.1002/hep.29825
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发表时间：
2018
期刊：
影响因子：
13.5
通讯作者：
Atkinson S
中科院分区：
文献类型：
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作者：
Atkinson S
我们饶有兴趣地阅读了Louvet等人在《肝脏学》上发表的文章。(1)强调影响重度酒精性肝炎患者预后的因素。他们发现，超过6个月，酒精复发，定义为消费量30克/天，是死亡率的独立预测因子，对风险比（HR）具有剂量相关影响。饮酒行为对结果的影响也在类固醇和戊氧基茶碱治疗重度酒精性肝炎（STOPAH）试验中收集的数据中进行了研究。(2)在最初发表的分析中，患者被归类为禁欲或饮酒。第90天恢复饮酒与第450天的死亡率显著高于戒酒（HR，2.77; 95%置信区间[CI]，1.79-4.29; P< 0.00001）。(2)我们重新检查了这些数据试图复制剂量-
We read with interest the article published in HEPATOLOGY by Louvet et al.(1) highlighting factors influencing outcomes in people with severe alcoholic hepatitis. They found that beyond 6 months, alcohol relapse, defined as consumption of 30 g/day, was an independent predictor of mortality with a dose-related effect on the hazard ratio (HR). The effect of drinking behavior on outcome has also been examined in data collected in the Steroids and Pentoxyfylline for Severe Alcoholic Hepatitis (STOPAH) trial.(2) Patients were classified, in the original published analysis, as abstinent or drinking. A return to alcohol consumption at day 90 was associated with a significantly higher mortality at day 450 than abstinence (HR, 2.77; 95% confidence interval [CI], 1.79-4.29; P< 0.00001).(2) We have reexamined these data in an attempt to replicate the dose-