Modulation of value representation by social context in the primate orbitofrontal cortex
Modulation of value representation by social context in the primate orbitofrontal cortex
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DOI：
10.1073/pnas.1111715109
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发表时间：
2012-02-07
影响因子：
11.1
通讯作者：
Duhamel, Jean-Rene
中科院分区：
文献类型：
--
作者：
Azzi, Joao C. B.;Sirigu, Angela;Duhamel, Jean-Rene
灵长类动物的生存依赖于它们理解社会环境的能力，它们的行为往往受到社会环境的影响。我们报告说，眶额皮层，一个涉及动机和奖励的大脑区域，对社会信息进行了调整。猕猴们努力为自己和两个猴子伙伴收集奖励。在行为上，猴子区分了小奖励和大奖励的信号，以及只给自己奖励和给自己和另一只猴子奖励的信号，在这两种情况下，前者比后者更受欢迎。在这项任务中记录的单个神经元编码了视觉线索的意义，这些线索预测了未来奖励的大小，以及在社会背景下获得的奖励的激励价值。此外，神经元活动被发现跟踪瞬间的社会偏好和合作伙伴的身份和社会地位。因此，眶额皮质包含了评估社会信息的关键神经元机制。
Primates depend for their survival on their ability to understand their social environment, and their behavior is often shaped by social circumstances. We report that the orbitofrontal cortex, a brain region involved in motivation and reward, is tuned to social information. Macaque monkeys worked to collect rewards for themselves and two monkey partners. Behaviorally, monkeys discriminated between cues signaling small and large rewards, and between cues signaling rewards to self only and reward to both self and another monkey, with a preference for the former over the latter in both instances. Single neurons recorded during this task encoded the meaning of visual cues that predicted the magnitude of future rewards, as well as the motivational value of rewards obtained in a social context. Furthermore, neuronal activity was found to track momentary social preferences and partner's identity and social rank. The orbitofrontal cortex thus contains key neuronal mechanisms for the evaluation of social information.