Exposure to polycyclic aromatic hydrocarbon mixtures and early kidney damage in Mexican indigenous population
Exposure to polycyclic aromatic hydrocarbon mixtures and early kidney damage in Mexican indigenous population
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DOI：
10.1007/s11356-021-12388-w
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发表时间：
2021-01-12
影响因子：
5.8
通讯作者：
Diaz de Leon-Martinez, Lorena
中科院分区：
文献类型：
--
作者：
Flores-Ramirez, Rogelio;Ortega-Romero, Manolo;Diaz de Leon-Martinez, Lorena
墨西哥土著社区的传统和习惯包括使用木材和生物质燃烧来烹饪食物，这会产生大量烟雾，从而造成家庭内部污染。这种烟雾由多环芳烃 (PAH) 的复杂混合物组成，高浓度接触会导致致癌、基因毒性作用和一些慢性肺部和心血管疾病；然而，很少有研究将肾脏健康与多环芳烃暴露联系起来。因此，本研究的目的是评估墨西哥瓦斯特卡波托西纳土著居民中 10 种 PAH 羟基化代谢物 (OH-PAH) 及其与早期肾损伤生物标志物（半胱氨酸蛋白酶抑制剂-C (Cys-C)）、骨桥蛋白 (OPN)、视黄醇结合蛋白-4 (RPB-4) 和中性粒细胞明胶酶相关脂质运载蛋白 (NGAL) 的相关性。结果表明 100% 的研究人群中存在 OH-PAH 和肾损伤生物标志物。 OH-PAH 按以下频率顺序显示：1-OH-PYR > 4-OH-PHE > 2-OH-NAP > 1-OH-NAP > 9-OH-FLU > 3-OH-FLU > 2-OH-FLU > 3-OH-PHE，检测百分比如下： 97.6、87.8、78、73.2、68.3、分别为 31.7%、14.6% 和 12.2%。 NGAL 和 RBP-4 存在于超过 85% 的人群中，平均浓度分别为 78.5 +/- 143.9 和 139.4 +/- 131.7 ng/g 肌酐，OPN (64%) 的平均浓度为 642.6 +/- 723.3 ng/g g 肌酐，Cys-C 的平均浓度为 33.72 +/- 131.7 ng/g 肌酐。 44.96 纳克/克肌酐。研究发现 1-OH-NAP、2-OH-NAP、9-OH-FLU 和 4-OH-PHE 与早期肾损伤的四种生物标志物之间存在相关性。 3-OH-FLU 与 OPN 和 1-OH-PYR 与 NGAL、OPN 和 RPB-4 显着相关。
The traditions and habits of indigenous communities in Mexico include the use of wood and biomass burning to cook their food, which generates large amounts of smoke and therefore pollution inside the households. This smoke is composed of a complex mixture of polycyclic aromatic hydrocarbons (PAHs) which at high levels of exposure cause carcinogenic, genotoxic effects and some chronic pulmonary and cardiovascular diseases; however, few studies relate kidney health with exposure to PAHs. Thus, the aim of this study was the evaluation of 10 hydroxylated metabolites of PAHs (OH-PAHs), and their correlation with biomarkers of early kidney damage renal (cystatin-C (Cys-C)), osteopontin (OPN), retinol-binding protein-4 (RPB-4), and neutrophil gelatinase-associated lipocalin (NGAL) in the indigenous population of the Huasteca Potosina in Mexico. The results demonstrate the presence of the OH-PAHs and kidney damage biomarkers in 100% of the study population. The OH-PAHs were shown in the following order of frequency, 1-OH-PYR > 4-OH-PHE > 2-OH-NAP > 1-OH-NAP > 9-OH-FLU > 3-OH-FLU > 2-OH-FLU > 3-OH-PHE and with the following percentages of detection 97.6, 87.8, 78, 73.2, 68.3, 31.7, 14.6, and 12.2%, respectively. NGAL and RBP-4 were present in above 85% of the population, with mean concentrations of 78.5 +/- 143.9 and 139.4 +/- 131.7 ng/g creatinine, respectively, OPN (64%) with a mean concentration of 642.6 +/- 723.3 ng/g g creatinine, and Cys-C with a mean concentration of 33.72 +/- 44.96 ng/g creatinine. Correlations were found between 1-OH-NAP, 2-OH-NAP, 9-OH-FLU, and 4-OH-PHE and the four biomarkers of early kidney damage. 3-OH-FLU with OPN and 1-OH-PYR correlated significantly with NGAL, OPN, and RPB-4.