Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders
复制标题
DOI：
10.1007/s00406-013-0472-6
复制
发表时间：
2014-06-01
影响因子：
4.7
通讯作者：
Uchitomi, Yosuke
中科院分区：
文献类型：
--
作者：
Nagao, Shigeto;Yokota, Osamu;Uchitomi, Yosuke
为了研究神经退行性疾病（包括嗜银颗粒病（AGD））与晚发性精神分裂症和妄想障碍（LOSD;发病年龄>= 40岁）之间的关系，我们对23例LOSD患者、71例年龄匹配的正常对照和22例精神疾病对照（11例抑郁症、6例人格障碍、2例双相情感障碍和3例神经症患者）进行了病理检查。在所有LOSD病例中（与年龄匹配的正常对照组相比），路易体病（LBD）、AGD和皮质基底节变性（CBD）的频率分别为26.1%（11.3%）、21.7%（8.5%）和4.3%（0.0%）。无一例单纯阿尔茨海默病（AD）。LOSD患者LBD、AGD和CBD的总频率显著高于正常对照组。嗜银颗粒显着更严重的LOSD比对照组，但几乎完全限于边缘系统和邻近的颞叶皮层。在≥ 65岁的LOSD患者中（与年龄匹配的正常对照组相比），LBD和AGD的频率分别为36.4%（19.4%）和36.4%（8.3%），LOSD患者AGD的频率明显高于正常对照组。在LOSD患者中，
To study the relationship between neurodegenerative diseases including argyrophilic grain disease (AGD) and late-onset schizophrenia and delusional disorders (LOSD; onset >= 40 years of age), we pathologically examined 23 patients with LOSD, 71 age-matched normal controls, and 22 psychiatric disease controls (11 depression, six personality disorder, two bipolar disorders, and three neurotic disorders cases). In all LOSD cases (compared to age-matched normal controls), the frequencies of Lewy body disease (LBD), AGD, and corticobasal degeneration (CBD) were 26.1 % (11.3 %), 21.7 % (8.5 %), and 4.3 % (0.0 %), respectively. There was no case of pure Alzheimer's disease (AD). The total frequency of LBD, AGD, and CBD was significantly higher in LOSD cases than in normal controls. Argyrophilic grains were significantly more severe in LOSD than in controls, but were almost completely restricted to the limbic system and adjacent temporal cortex. In LOSD patients whose onset occurred at >= 65 years of age (versus age-matched normal controls), the frequencies of LBD and AGD were 36.4 % (19.4 %) and 36.4 % (8.3 %), respectively, and AGD was significantly more frequent in LOSD patients than in normal controls. In LOSD patients whose onset occurred at