Protective role of miR-23b-3p in kainic acid-induced seizure
Protective role of miR-23b-3p in kainic acid-induced seizure
复制标题
miR-23b-3p 在红藻氨酸诱导的癫痫发作中的保护作用
DOI：
10.1097/wnr.0000000000000610
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发表时间：
2016-07-06
期刊：
影响因子：
1.7
通讯作者：
Zheng, Honghua
中科院分区：
文献类型：
--
作者：
Zhan, Lianbo;Yao, Yi;Zheng, Honghua
Dysregulation of microRNAs has been proposed to contribute toward epilepsy. The miRNA miR-23b-3p has been found to protect against neuronal apoptosis and the production of reactive oxygen species. In this study, we assessed the potential role of miR-23b-3p in the kainic acid (KA)-induced seizure model. We found that miR-23b-3p levels were significantly decreased in the brain cortex of mice and in cultured mouse primary neurons treated with KA. Importantly, supplement of miR-23b-3p agomir by an intacerebroventricular injection alleviated seizure behaviors and abnormal cortical electroencephalogram recordings in KA-treated mice. Together, these results indicate that miR-23b-3p plays a crucial role in suppressing seizure formation in experimental models of epilepsy and that miR-23b-3p supplement may be a potential anabolic strategy for ameliorating seizure.
