BASAL AND 24-H C-PEPTIDE AND INSULIN-SECRETION RATE IN NORMAL MAN
BASAL AND 24-H C-PEPTIDE AND INSULIN-SECRETION RATE IN NORMAL MAN
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DOI：
10.1007/bf01788901
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发表时间：
1987-01-01
期刊：
影响因子：
8.2
通讯作者：
ALBERTI, KGMM
中科院分区：
文献类型：
--
作者：
KRUSZYNSKA, YT;HOME, PD;ALBERTI, KGMM
糖尿病患者的胰岛素输送不当引起的代谢异常的理解需要一个知识的24小时和基础胰岛素分泌率在正常man. We生物合成的人C-肽，以确定其动力学参数在10个正常受试者和应用这些测量血浆浓度在相同的主题，以确定胰腺分泌率。通过以10、19和26 nmol/h的速率分步引发输注生物合成的人C-肽测量的代谢清除率为4.7 ± 0.1。0.7 (.+-. SD）ml. cntdot。kg-1. min ~（-1），与输注速率无关。部分清除率（T1/2，26 ±. 3分钟）和分布体积（0.178 ±. 0.039 l/kg）根据停止最高速率输注后的浓度下降计算。从02.00至07.00小时期间的C-肽代谢清除率和血浆浓度计算的基础胰岛素分泌为1.3 ±。0.4 U/h。标准高碳水化合物饮食24小时内的总胰岛素分泌量为63 ±-。15 U，根据C肽浓度曲线下面积计算。因此，基础胰岛素分泌占50 . ±. 8%的胰岛素分泌量。虽然只有5.6 .+-. 24 h尿C肽检出率为1.1%，尿C肽排泄量与24 h尿C肽分泌量呈显著正相关（r = 0.74，p < 0.02）。
An understanding of the metabolic abnormalities rising from inappropriate insulin delivery in diabetic patients demands a knowledge of 24-h and basal insulin secretion rates in normal man. We have used biosynthetic human C-peptide to determine its kinetic parameters in 10 normal subjects and applied these to measurements of plasma concentrations in the same subjects to determine pancreatic secretion rate. Metabolic clearance rate measured by stepped primed infusion of biosynthetic human C-peptide at rates of 10, 19 and 26 nmol/h was 4.7 .+-. 0.7 (.+-. SD) ml .cntdot. kg-1 .cntdot. min-1, and was independent of infusion rate. Fractional clearance (T1/2, 26 .+-. 3 min) and distribution volume (0.178 .+-. 0.039 l/kg) were calculated from the decline in concentration after cessation of the highest rate infusion. Basal insulin secretion calculated from the C-peptide metabolic clearance rate and plasma concentrations for the period 02.00 to 07.00 hours was 1.3 .+-. 0.4 U/h. Over 24 h total insulin secretion on a standard high carbohydrate diet was 63 .+-. 15 U, calculated from the area under the C-peptide concentration curve. Basal insulin secretion, therefore, accounted for 50 .+-. 8% of total insulin secretion. Although only 5.6 .+-. 1.1% of C-peptide was detected in 24 h urine collections, urinary C-peptide excretion was significantly related to 24-h C-peptide secretion (r = 0.74, p < 0.02).