Physiological Predictors of Weight Regain at 1-Year Follow-Up in Weight-Reduced Adults with Obesity
Physiological Predictors of Weight Regain at 1-Year Follow-Up in Weight-Reduced Adults with Obesity
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DOI：
10.1002/oby.22476
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发表时间：
2019-06-01
期刊：
影响因子：
6.9
通讯作者：
Martins, Catia
中科院分区：
文献类型：
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作者：
Nymo, Siren;Coutinho, Silvia R.;Martins, Catia
目的探讨体重减轻（WL）后静息代谢率（RMR）、运动性能量消耗（EIEE）和食欲的变化与1年后体重恢复的关系。方法36名肥胖成年人接受了8周的极低能量饮食，随后进行了4周的再喂养和1年的维持计划。在基线、第13周和第1年测量RMR、EIEE、食欲等级和活性胃饥饿素、肽YY、胰高血糖素样肽-1、胆囊收缩素和胰岛素浓度。结果在第13周达到17% WL（-20 +/- 5 kg [平均值+/- SD];范围：-11.7至-32.2 kg; P < 0.001）。1年后，体重恢复为2.5 +/- 9.0 kg（不显著），范围为-18.2至22.5 kg。在第13周时，脂肪量和去脂肪量均减少（分别为-17.9 +/-4.8和-2.9 +/-2.7 kg; P < 0.001），而在第1年时仅脂肪量减少。WL与RMR、EIEE和空腹/餐后胰岛素降低相关（均P < 0.001），与空腹饥饿（P < 0.01）和空腹/餐后活性ghrelin增加相关（P < 0.001）。1年时RMR、EIEE或食欲变化与WL和体重恢复之间无显著相关性。结论：没有明确的证据表明WL后RMR、EIEE或食欲的变化可以预测1年后的体重恢复，但需要更大规模的研究来证实这些结果。
Objective This study aimed to assess whether changes in resting metabolic rate (RMR), exercise-induced energy expenditure (EIEE), and appetite following weight loss (WL) are associated with weight regain at 1 year. Methods Thirty-six adults with obesity underwent 8 weeks of a very-low-energy diet, followed by 4 weeks of refeeding and a 1-year maintenance program. RMR, EIEE, appetite ratings, and active ghrelin, peptide YY, glucagon-like peptide-1, cholecystokinin, and insulin concentrations were measured at baseline, week 13, and 1 year. Results A 17% WL (-20 +/- 5 kg [mean +/- SD]; range: -11.7 to -32.2 kg; P < 0.001) was achieved at week 13. After 1 year, weight regain was 2.5 +/- 9.0 kg (not significant), ranging from -18.2 to 22.5 kg. Both fat mass and fat-free mass were reduced at week 13 (-17.9 +/- 4.8 and -2.9 +/- 2.7 kg, respectively; P < 0.001), while only loss of fat mass was sustained at 1 year. WL was associated with reduced RMR, EIEE, and fasting/postprandial insulin (all P < 0.001), as well as increased fasting hunger (P < 0.01) and fasting/postprandial active ghrelin (P < 0.001). There were no significant correlations between changes in RMR, EIEE, or appetite with WL and weight regain at 1 year. Conclusions No clear evidence emerged that changes in RMR, EIEE, or appetite following WL can predict weight regain at 1 year, but larger studies are needed to confirm these results.