PRODUCTION OF ERYTHROCYTES THAT CONTAIN FETAL HEMOGLOBIN IN ANEMIA - TRANSIENT INVIVO CHANGES
PRODUCTION OF ERYTHROCYTES THAT CONTAIN FETAL HEMOGLOBIN IN ANEMIA - TRANSIENT INVIVO CHANGES
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DOI：
10.1172/jci109286
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发表时间：
1979-01-01
影响因子：
15.9
通讯作者：
ZINKHAM, WH
中科院分区：
文献类型：
--
作者：
DOVER, GJ;BOYER, SH;ZINKHAM, WH
对4例从贫血中恢复的F细胞（即含有胎儿[F] Hb的红细胞）进行的一系列显微镜免疫扩散试验表明，含有HbF的循环网状红细胞（F网状红细胞）的百分比最初增加，随后含有HbF的成熟红细胞（F红细胞）的百分比增加。在1例对缺铁性贫血治疗有反应的患者中，F网织红细胞的平均百分比从4.8 +-增加。1.1至16.0 .+-。2.8%(平均+-。SD)，而F红细胞的平均水平从3.5 +-升高。0.7到7.2 .+-。0.6%。两名患有短暂性红细胞减少症的正常儿童的F网织红细胞百分比为71.3 +-。6.7和41.5 .+-。恢复红细胞生成时，分别为1.5%。随着恢复，这些值下降到最终测量值33.7 +-。4.7和12.6 .+。1.1%,分别。在患有镰状细胞性贫血的青少年中，f -网织红细胞的百分比在0.6 +-之间波动。1.1和34.0 .+-。2.8%，并且与鼻咽癌治疗相关的所有网织红细胞总量的上升平行。F细胞和非F细胞的产生显然分别受到调控。f细胞的产生在脱离红细胞生成抑制时被优先刺激，在抑制开始时被选择性地抑制。在摆脱红细胞生成抑制的过程中，体内f细胞的生成与体外培养的红细胞干细胞相似。患有镰状细胞性贫血的个体，像没有血红蛋白病的个体一样，可以改变其f细胞生成的相对水平。
Serial microscopic immunodiffusion assays of F cells, i.e., erythrocytes that contain fetal [F] Hb, in 4 individuals recoverying from anemia demonstrated initial increases in the percentage of circulating reticulocytes that contain HbF (F reticulocytes) and subsequent increases in the percentage of mature erythrocytes that contain HbF (F erythrocytes). In 1 individual responding to therapy for Fe-deficiency anemia, the average percentage of F reticulocytes increased from 4.8 .+-. 1.1 to 16.0 .+-. 2.8% (mean .+-. SD), while the mean level of F erythrocytes increased from 3.5 .+-. 0.7 to 7.2 .+-. 0.6%. Two normal children with transient erythroblastopenia exhibited F reticulocyte percentages of 71.3 .+-. 6.7 and 41.5 .+-. 1.5%, respectively, when erythropoiesis resumed. With recovery, these values fell to finally measured values of 33.7 .+-. 4.7 and 12.6 .+-. 1.1%, respectively. In an adolescent with sickle cell anemia, F-reticulocyte percentages fluctuated between 0.6 .+-. 1.1 and 34.0 .+-. 2.8% and paralleled the rise and all of total reticulocytes associated with therapy for a nasopharyngeal carcinoma. The production of F cells and non-F cells are apparently separately regulated. F-cell production is preferentially stimulated during escape from erythropoietic suppression and selectively depressed at the start of suppression. During escape from erythropoietic suppression, F-cell production in vivo resembles that reported for in vitro cultures of erythroid stem cells. Individuals with sickle cell anemia, like individuals without hemoglobinopathies, can change their relative level of F-cell production.