Impact of Catheter Ablation on Stroke, Cognitive Decline and Dementia.
Impact of Catheter Ablation on Stroke, Cognitive Decline and Dementia.
复制标题
DOI：
10.15420/aer.2021.42
复制
发表时间：
2021-10
影响因子：
3
通讯作者：
Bunch TJ
中科院分区：
文献类型：
--
作者：
Burnham TS;Scott ML;Steinberg BA;Varela DL;Zenger B;Bunch TJ
房颤一直与多种形式的痴呆相关，包括特发性痴呆。与使用抗心律失常药物治疗的患者相比，房颤导管消融后的结果是有利的，患者的生活质量更好，无心律失常生存，住院率更低。在大型国家和医疗保健系统数据库中，与不消融的房颤管理相比，导管消融始终与较低的卒中发生率相关。多项观察性试验表明，导管消融也与认知能力下降、痴呆和改善认知测试的风险降低有关，这可以通过多种途径来解释。需要长期、充分的随机试验来确定导管消融在房颤治疗中的作用，以降低认知能力下降、中风和痴呆的风险。
AF has been consistently associated with multiple forms of dementia, including idiopathic dementia. Outcomes after catheter ablation for AF are favourable and patients experience a better quality of life, arrhythmia-free survival, and lower rates of hospitalisation compared to patients treated with antiarrhythmic drugs. Catheter ablation is consistently associated with lower rates of stroke compared to AF management without ablation in large national and healthcare system databases. Multiple observational trials have shown that catheter ablation is also associated with a lower risk of cognitive decline, dementia and improved cognitive testing that can be explained through a variety of pathways. Long-term, adequately powered, randomised trials are required to define the role of catheter ablation in the management of AF as a means to lower the risk of cognitive decline, stroke and dementia.