Age-related differences in brain activations during spatial memory formation in a well-learned virtual Morris water maze (vMWM) task.
Age-related differences in brain activations during spatial memory formation in a well-learned virtual Morris water maze (vMWM) task.
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在充分学习的虚拟莫里斯水迷宫（vMWM）任务中，空间记忆形成过程中大脑激活的年龄相关差异。
DOI：
10.1016/j.neuroimage.2019.116069
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发表时间：
2019
期刊：
影响因子：
5.7
通讯作者：
Magnusson,KathyR
中科院分区：
文献类型：
--
作者：
Reynolds,NadjalisseC;Zhong,JimmyY;Clendinen,CheritaA;Moffat,ScottD;Magnusson,KathyR
目前的研究应用了一种基于啮齿动物的虚拟莫里斯水迷宫（vMWM）协议，以调查年轻和老年男性成年人之间搜索性能和大脑激活的差异。所有参与者在fMRI扫描仪中执行任务之前都完成了实验室练习和测试。在功能磁共振成像扫描期间的行为表现-以校正的累积接近度（CCProx）来测量目标-表明，一个年龄较大的表现良好的子组达到了与年轻人相当的搜索准确性水平，而另一个年龄较大的表现不佳的子组则表现出持续低于年龄较大的表现良好的人和年轻人的搜索准确性水平。关于大脑激活，年轻人的小脑和楔叶比所有老年人以及老年表现不佳者表现出更大的激活。年龄较大的表现好的表现比年龄较大的表现差的眶额皮质（BA 10/11），以及在楔和小脑的激活。大脑行为相关性进一步表明，参与视觉控制（小脑，舌回）和自我中心空间处理（前运动皮层，楔前叶）的区域的激活与搜索准确性呈正相关（即，更接近目标）。值得注意的是，前海马的激活与年轻人的搜索准确性（CCProx倒置）呈正相关，但在老年人中则不然。总之，这些发现暗示眶额皮层和小脑在老年人的执行和视觉空间处理中发挥着至关重要的作用，支持与年龄相关的空间记忆功能从海马向前额皮质的补偿性转移的建议。
The current study applied a rodent-based virtual Morris water maze (vMWM) protocol to an investigation of differences in search performance and brain activations between young and older male human adults. All participants completed in-lab practice and testing before performing the task in the fMRI scanner. Behavioral performance during fMRI scanning – measured in terms of corrected cumulative proximity (CCProx) to the goal – showed that a subgroup of older good performers attained comparable levels of search accuracy to the young while another subgroup of older poor performers exhibited consistently lower levels of search accuracy than both older good performers and the young. With regard to brain activations, young adults exhibited greater activations in the cerebellum and cuneus than all older adults, as well as older poor performers. Older good performers exhibited higher activation than older poor performers in the orbitofrontal cortex (BA 10/11), as well as in the cuneus and cerebellum. Brain-behavior correlations further showed that activations in regions involved in visuomotor control (cerebellum, lingual gyrus) and egocentric spatial processing (premotor cortex, precuneus) correlated positively with search accuracy (i.e., closer proximity to goal) in all participants. Notably, activations in the anterior hippocampus correlated positively with search accuracy (CCProx inversed) in the young but not in the old. Taken together, these findings implicated the orbitofrontal cortex and the cerebellum as playing crucial roles in executive and visuospatial processing in older adults, supporting the proposal of an age-related compensatory shift in spatial memory functions away from the hippocampus toward the prefrontal cortex.