The relationships between age, sex, and the incidence of dementia and Alzheimer disease - A meta-analysis
The relationships between age, sex, and the incidence of dementia and Alzheimer disease - A meta-analysis
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DOI：
10.1001/archpsyc.55.9.809
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发表时间：
1998-09-01
影响因子：
--
通讯作者：
Hall, KS
中科院分区：
文献类型：
--
作者：
Gao, S;Hendrie, HC;Hall, KS
背景：痴呆和阿尔茨海默病（AD）的患病率研究报告与年龄呈正相关。然而，在最老的老类协会的趋势一直是讨论的主题。性别与AD之间的关系与这些研究不一致。患病率受生存率和发病率的影响。发病率提供了一个更好的衡量疾病risk.Methods：英语文章确定通过MEDLINE搜索“发病率痴呆”和“发病率阿尔茨海默病”进行了检查，并从确定的文章参考文献进行了审查。荟萃分析中纳入了基于人群的研究，这些研究使用个人访谈、标准临床诊断标准（痴呆症的DSM-III，国家神经和交流障碍研究所和中风-阿尔茨海默病及相关疾病协会的AD）和报告年龄特异性发病率。从选定的研究中提取数据并加以核实。混合效应模型中使用的元分析，以适应异质性的study.Results：事件痴呆和AD与一个显着的二次年龄效应表明，发病率的增加减缓与年龄的增加，虽然没有迹象表明发病率下降本身。女性发展痴呆症和AD的发病率相对于男性的比值比分别为1.18（95%置信区间，0.95-1.46）和1.56（95%置信区间，1.16-2.10），分别为Conclusions：AD和痴呆症的发病率的加速减缓随着年龄的增加，虽然我们没有发现任何证据的速率下降。女性患AD的风险高于男性。
Background: Prevalence studies on dementia and Alzheimer disease (AD) have reported a positive association with age. However, the trend of the association in the oldest-old categories has been the subject of discussion. The relationship between sex and AD has been inconsistent with these studies. Prevalence rates are influenced by the survival and disease incidence. Incidence rates provide a better measure of disease risk.Methods: English-language articles identified through a MEDLINE search on "incidence dementia" and "incidence Alzheimer's disease" were examined and references from identified articles were reviewed. Population-based studies using personal interviews, standard clinical diagnosis criteria (DSM-III for dementia, National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorder Association for AD) and reporting age-specific incidence rates were included in the meta-analysis. Data from the selected studies were extracted and verified. Mixed-effect models were used in the mete-analysis to accommodate the heterogeneity of the studies.Results: Incident dementia and AD are associated with a significant quadratic age effect indicating that the increase in incidence rates slows down with the increase in age, although there is no sign of a decline in the incidence rates themselves. The odds ratios for women to develop incidence of dementia and AD relative to men are 1.18 (95% confidence interval, 0.95-1.46) and 1.56 (95% confidence interval, 1.16-2.10), respectively.Conclusions: The acceleration of incidence rates for AD and dementia slows down with the increase in age, although we find no evidence of a rate decline. Women are at higher risk of developing AD than men.