PLASMA-CONCENTRATIONS OF TRANSSULFURATION PATHWAY PRODUCTS DURING NASOENTERAL AND INTRAVENOUS HYPERALIMENTATION OF MALNOURISHED PATIENTS
PLASMA-CONCENTRATIONS OF TRANSSULFURATION PATHWAY PRODUCTS DURING NASOENTERAL AND INTRAVENOUS HYPERALIMENTATION OF MALNOURISHED PATIENTS
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DOI：
10.1093/ajcn/42.4.577
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发表时间：
1985-01-01
影响因子：
7.1
通讯作者：
RUDMAN, D
中科院分区：
文献类型：
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作者：
CHAWLA, RK;BERRY, CJ;RUDMAN, D
我们监测了 11 名营养不良的非肝硬化患者和 10 名恶病质肝硬化受试者在使用 Vivonex（Norwich-Eaton Pharmaceuticals，Norwich，NY）进行鼻肠营养或使用 FreAmine III（American McGaw，Irvine，CA）进行全肠外营养（TPN）之前和期间的转硫途径产物的血浆浓度。在混合饮食的肝硬化病例中，牛磺酸、半胱氨酸、血浆谷胱甘肽和游离胆碱的水平低于正常。在鼻肠营养过度期间，蛋氨酸升高，而半胱氨酸、谷胱甘肽和游离胆碱水平仍然下降。在 TPN 期间，牛磺酸、半胱氨酸、蛋白质结合半胱氨酸、谷胱甘肽、游离胆碱和磷脂酰胆碱的水平降低，蛋氨酸水平升高。在吃混合饮食的非肝硬化病例中，只有游离胆碱浓度较低。在鼻肠营养过度期间，游离胆碱和总肉碱的血浆水平均下降。 TPN期间，胱氨酸、蛋白结合半胱氨酸、总肉碱、游离胆碱和磷脂酰胆碱的血浆水平低于正常。这些数据表明，在使用 FreAmine III 进行 TPN 期间，肝硬化和非肝硬化患者中转硫途径的几种产物的生物合成可能不足。
We have monitored the plasma concentrations of products of the transsulfuration pathway in 11 undernourished noncirrhotic patients, and in 10 cachectic cirrhotic subjects, before and during nasoenteral nutrition ith Vivonex (Norwich-Eaton Pharmaceuticals, Norwich, NY) or total parenteral nutrition (TPN) with FreAmine III (American McGaw, Irvine, CA). In the cirrhotic cases eating a mixed diet, levels of taurine, cysteine, plasma glutathione, and free choline were subnormal. During nasoenteral hyperalimentation, methionine was elevated while cysteine, glutathione, and free choline levels remained depressed. During TPN, levels of taurine, cysteine, protein-bound cysteine, glutathione, free choline, and phosphatidyl choline were depressed and methionine was elevated. In the noncirrhotic cases eating a mixed diet, only the free choline concentration was low. During nasoenteral hyperalimentation, the plasma levels of both free choline and total carnitine were depressed. During TPN, plasma levels of cystine, protein-bound cysteine, total carnitine, free choline, and phosphatidyl choline were subnormal. These data suggest that biosynthesis of several products of the transsulfuration pathway may be inadequate in both cirrhotic and noncirrhotic patients during TPN with FreAmine III.