Novel strategies for improving dietary exposure assessment: Multiple data fusion is a more accurate measure than the traditional single-biomarker approach
Novel strategies for improving dietary exposure assessment: Multiple data fusion is a more accurate measure than the traditional single-biomarker approach
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DOI：
10.1016/j.tifs.2017.04.013
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发表时间：
2017-11-01
影响因子：
15.3
通讯作者：
Andres-Lacueva, Cristina
中科院分区：
文献类型：
--
作者：
Garcia-Aloy, Mar;Rabassa, Montserrat;Andres-Lacueva, Cristina
背景资料：准确测量食物摄入量是了解饮食与最佳健康状况或疾病风险之间联系的基石。代谢组学方法的应用正在通过将代谢谱与特定食物或饮食模式的摄入和/或在营养试验中调查人类健康状况相关联来彻底改变饮食评估领域。将膳食生物标志物与传统的膳食评估方法相结合被认为是解决膳食暴露fingerprinting.Scope和方法的复杂性的潜在策略：我们讨论了膳食评估方法和膳食生物标志物之间的现有方法。一个综合的方法，考虑到饮食调查问卷的数据与饮食生物标志物的测量emphasized.Key调查结果和结论：在新的战略，改善饮食暴露评估的趋势将受到饮食暴露生物标志物的发现和验证。在不同的策略中，多代谢物生物标志物小组比传统的单一生物标志物方法更可靠地估计饮食暴露。因此，使用饮食问卷沿着的数据与饮食生物标志物的测量相结合的方法被认为是改善饮食暴露评估的一种很好的策略。(C)2017爱思唯尔有限公司版权所有
Background: Accurate measurement of food intake is the cornerstone of understanding the links between diet and optimal health status or risk of disease. The utilization of metabolomics approaches is revolutionizing the field of dietary assessment by associating metabolic profiles with intake of specific foods or dietary patterns and/or investigating human health status in nutritional trials. Combining dietary biomarkers with conventional dietary assessment methods is considered a potential strategy for tackling the complexity of dietary exposure fingerprinting.Scope and approach: We discuss existing approaches among dietary assessment methods and dietary biomarkers. A combined approach taking into consideration data from dietary questionnaires with measurements of dietary biomarkers is emphasized.Key findings and conclusions: Trends in novel strategies for improving dietary exposure assessment will be influenced by the discovery and validation of dietary exposure biomarkers. Among different strategies, multi-metabolite biomarker panels enable more reliable estimation of dietary exposure than does the traditional single-biomarker approach. Therefore, a combined approach using data from dietary questionnaires along with measurements of dietary biomarkers is considered an excellent strategy for improving dietary exposure assessment. (C) 2017 Elsevier Ltd. All rights reserved.