A longitudinal study investigating neural processing of speech envelope modulation rates in children with (a family risk for) dyslexia
A longitudinal study investigating neural processing of speech envelope modulation rates in children with (a family risk for) dyslexia
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DOI：
10.1016/j.cortex.2017.05.007
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发表时间：
2017-08-01
期刊：
影响因子：
3.6
通讯作者：
Wouters, Jan
中科院分区：
文献类型：
--
作者：
De Vos, Astrid;Vanvooren, Sophie;Wouters, Jan
最近的证据表明，在言语中，神经振荡与时间信息同步的根本赤字可能是阅读障碍中语音处理问题的基础。由于先前的研究是在学龄儿童或成人的横截面进行的，因此与阅读习得和阅读障碍有关的神经听觉加工的发育方面仍有待研究。目前的纵向研究跟踪了68名从阅读者（5岁）到开始读者（7岁）和更高级读者（9岁）的儿童。 36名儿童患有阅读障碍的家庭风险，最终14名儿童患有阅读障碍。在每个时间点收集了对应于音节和音素速率的4和20 Hz调制的听觉稳态响应的脑电图记录。我们的结果表明，围绕阅读习得的开始，神经同步与音素速率调制的增加有所增加。这种效果与以后的阅读和语音技能负相关，表明在语音速率上表现出最大的神经同步增长，发展最差的阅读和语音能力。因此，发现在开始阅读障碍的开始和更高级的读者中，发现神经同步与音素速率调制率明显更高。我们发现关于神经同步与音节率没有发育影响，也没有家庭阅读障碍的任何影响。总而言之，我们的发现表明，阅读指导的开始与对音素速率调制的神经反应性的增加一致，并且这种增加的程度与阅读发展的（结果）有关。因此，从阅读习得开始，阅读障碍儿童持续证明了与音素速率的非典型神经同步。 （c）2017 Elsevier Ltd.保留所有权利。
Recent evidence suggests that a fundamental deficit in the synchronization of neural oscillations to temporal information in speech may underlie phonological processing problems in dyslexia. Since previous studies were performed cross-sectionally in school-aged children or adults, developmental aspects of neural auditory processing in relation to reading acquisition and dyslexia remain to be investigated. The present longitudinal study followed 68 children during development from pre-reader (5 years old) to beginning reader (7 years old) and more advanced reader (9 years old). Thirty-six children had a family risk for dyslexia and 14 children eventually developed dyslexia. EEG recordings of auditory steady-state responses to 4 and 20 Hz modulations, corresponding to syllable and phoneme rates, were collected at each point in time. Our results demonstrate an increase in neural synchronization to phoneme-rate modulations around the onset of reading acquisition. This effect was negatively correlated with later reading and phonological skills, indicating that children who exhibit the largest increase in neural synchronization to phoneme rates, develop the poorest reading and phonological skills. Accordingly, neural synchronization to phoneme-rate modulations was found to be significantly higher in beginning and more advanced readers with dyslexia. We found no developmental effects regarding neural synchronization to syllable rates, nor any effects of a family risk for dyslexia. Altogether, our findings suggest that the onset of reading instruction coincides with an increase in neural responsiveness to phoneme-rate modulations, and that the extent of this increase is related to (the outcome of) reading development. Hereby, dyslexic children persistently demonstrate atypically high neural synchronization to phoneme rates from the beginning of reading acquisition onwards. (C) 2017 Elsevier Ltd. All rights reserved.