Virology and cell biology of the hepatitis C virus life cycle - An update
Virology and cell biology of the hepatitis C virus life cycle - An update
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DOI：
10.1016/j.jhep.2014.06.031
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发表时间：
2014-11-01
影响因子：
25.7
通讯作者：
Cosset, Francois-Loic
中科院分区：
文献类型：
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作者：
Dubuisson, Jean;Cosset, Francois-Loic
丙型肝炎病毒（HCV）是引起肝炎、肝硬化和肝细胞癌的重要人类病原体。它给世界公共卫生带来了严重问题，因为预计未来几十年，有进展性肝病风险的慢性丙型肝炎患者人数将大幅增加。然而，新的抗病毒分子的出现正在逐步改变丙型肝炎治疗的格局。寻找新的抗 HCV 疗法也是更好地了解 HCV 如何与其宿主相互作用的推动力，并且 HCV 生命周期的各个步骤都取得了重大进展。在这里，我们回顾了有关丙型肝炎病毒生命周期以及与宿主因素和途径相互作用的快速增长知识的最新进展。 (C) 2014 年欧洲肝脏研究协会。由 Elsevier B.V. 出版。保留所有权利。
Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis and hepatocellular carcinoma. It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk of progressive liver disease is projected to increase significantly in the next decades. However, the arrival of new antiviral molecules is progressively changing the landscape of hepatitis C treatment. The search for new anti-HCV therapies has also been a driving force to better understand how HCV interacts with its host, and major progresses have been made on the various steps of the HCV life cycle. Here, we review the most recent advances in the fast growing knowledge on HCV life cycle and interaction with host factors and pathways. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.