Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression.
Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression.
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发表时间：
1994
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通讯作者：
H. Crawford;L. Matrisian
中科院分区：
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作者：
H. Crawford;L. Matrisian
基质金属蛋白酶（matrix metalloproteinases，MMPs）参与了许多正常和病理过程中的组织重塑，尤其是在肿瘤的侵袭和转移过程中起重要作用。MMP过表达与几种肿瘤类型的进展阶段相关。由于肿瘤细胞的异常性质，已经假设肿瘤细胞本身负责这种异常MMP产生。然而，最近的原位杂交实验已经确定，虽然MMP家族的一些成员在肿瘤细胞内表达，但许多在紧邻肿瘤组织的正常基质成分中发现。在这篇综述中，我们讨论了肿瘤和基质金属蛋白酶在肿瘤进展中的潜在作用。此外，使用MMP的表达作为一个参考点，我们讨论了一些潜在的机制参与肿瘤/宿主的相互作用。
The matrix metalloproteinases (MMPs) have been associated with tissue remodeling in many normal and pathological processes, and in particular are thought to be critical for tumor invasion and metastasis. MMP overexpression has been correlated with the stage of progression in several tumor types. Because of the aberrant nature of tumor cells, it has been assumed that the tumor cells themselves are responsible for this abnormal MMP production. However, recent in situ hybridization experiments have determined that, while some members of the MMP family are expressed within neoplastic cells, many are found in normal stromal components immediately adjacent to the tumor tissue. In this review, we address the potential roles of both tumor and stromal MMPs in tumor progression. Also, using MMP expression as a point of reference, we discuss some of the potential mechanisms involved in tumor/host interactions.