An fMRI study of neuronal specificity of an acupoint: Electroacupuncture stimulation of Yanglingquan (GB34) and its sham point
An fMRI study of neuronal specificity of an acupoint: Electroacupuncture stimulation of Yanglingquan (GB34) and its sham point
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DOI：
10.1016/j.neulet.2009.08.009
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发表时间：
2009-10-16
影响因子：
2.5
通讯作者：
Bae, Hyung-sup
中科院分区：
文献类型：
--
作者：
Na, Byung-jo;Jahng, Geon-Ho;Bae, Hyung-sup
穴位的神经元特异性尚未得到fMRI研究结果的完全支持。本研究的目的是利用功能磁共振成像（fMRI）研究电针刺激（EAS）穴位的神经元特异性。对12名正常健康受试者在左侧小腿上按平衡顺序行GB34（阳陵泉）及其假点EAS时进行全脑功能MR成像。在解剖学上，GB34及其假点都属于L5脊柱节段。左侧GB34的EAS特异性激活右侧壳核、尾状体、屏状核、丘脑、小脑以及左侧尾状体、腹外侧丘脑和小脑，所有这些都与运动功能相关。在左侧GB34假点的EAS特异性激活右侧BA6、BA8、BA40、BA44、丘脑以及左侧丘脑和小脑。总之，这些发现表明，EAS在一个穴位和它的假点，在同一个脊髓节段，诱导特定的脑反应模式。这些发现支持穴位研究的神经元特异性。在GB34的EAS似乎更相关的运动功能比EAS在其假点，表明GB34穴位的特异性。本研究结果为穴位特异性的存在提供了神经生物学证据，尽管需要进一步的研究来更好地理解这种现象。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
The neuronal specificity of acupoints has not been entirely supported by the results of fMRI studies. The objective of this study was to investigate the neuronal specificity of an acupoint with electroacupuncture stimulation (EAS) using functional magnetic resonance imaging (fMRI). Functional MR imaging of the entire brain was performed in 12 normal healthy subjects during EAS of GB34 (Yanglingquan) and its sham point over the left leg in counter-balanced order. Anatomically, both GB34 and its sham point belong to the L5 spinal segment. EAS at the left GB34 specifically activated the right putamen, caudate body, claustrum, thalamus, cerebellum, as well as the left caudate body, ventral lateral thalamus, and cerebellum, all related to motor function. EAS at the sham point of the left GB34 specifically activated the right BA6, BA8, BA40, BA44, thalamus, as well as the left thalamus and cerebellum. Taken together, these findings suggest that EAS at an acupoint and its sham point, in the same spinal segment, induced specific cerebral response patterns. These findings support neuronal specificity of the acupoint studied. EAS at GB34 appears to be more related to motor function than EAS at its sham point, suggesting specificity of the GB34 acupoint. The results of this study provide neurobiological evidence for the existence of acupoint specificity, although further studies are necessary to better understand this phenomenon. (C) 2009 Elsevier Ireland Ltd. All rights reserved.