The influence of early postnatal nutrition on retinopathy of prematurity in extremely low birth weight infants
The influence of early postnatal nutrition on retinopathy of prematurity in extremely low birth weight infants
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DOI：
10.1016/j.earlhumdev.2010.05.015
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发表时间：
2010-06-01
影响因子：
2.5
通讯作者：
Weaver, R. Grey, Jr.
中科院分区：
文献类型：
--
作者：
Porcelli, Peter J.;Weaver, R. Grey, Jr.
背景：早产儿视网膜病变（ROP）是早产儿最常见的严重眼病。人乳可能对ROP有保护作用;然而，人乳的有益作用排除了随机试验。因此，我们进行了一项回顾性分析，比较出生后早期营养与ROP development.Objective：评价出生后早期营养状况与ROP surgical.Design/Methods的关系：营养数据收集的先天性阿加婴儿，BW 700- 1000 g。ROP手术是主要结局变量。由一名儿科眼科医生监督检查。所有婴儿每三周接受一次IM维生素A作为慢性肺部疾病预防（Tyson：NEJM，1999）。结果：BW和胎龄分别为867 +/- 85 g和26.3 +/- 1.2周（n=77，平均值+/-1 SD）。ROP手术婴儿（n = 11）在出生后第二周接受了更多的肠外营养（1648 mL）和更少的母乳（13.8 mL/kg-天）和维生素E（1.4 mg/kg-天）。母乳是ROP手术的阴性预测因子，比值比= 0.94。两组都符合维生素A的建议;然而，74%的人通过IM注射给药。两组均未达到维生素E的推荐标准。结论：母乳喂养、肠外营养量和维生素E摄入量是ROP手术的预测因素。IM维生素A注射提供了大部分维生素A;维生素E给药不足。改善母乳喂养率和维生素剂量选择可能会影响ROP手术率。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Background: Retinopathy of prematurity(ROP) is the most common serious ophthalmic disease in preterm infants. Human milk may provide a protective effect for ROP; however, beneficial effects of human milk preclude randomized trials. Therefore, we conducted a retrospective analysis comparing early postnatal nutrition with ROP development.Objective: Evaluate relationship between early postnatal nutriture and ROP surgery.Design/methods: Nutrition data was collected for inborn AGA infants, BW 700-1000g. ROP surgery was the primary outcome variable. A single pediatric ophthalmologist supervised examinations. All infants received triweekly IM vitamin A as chronic lung disease prophylaxis (Tyson: NEJM, 1999).Results: BW and gestational age were 867 +/- 85 g and 26.3 +/- 1.2 weeks (n=77, mean +/- 1SD). ROP surgery infants(n = 11) received more parenteral nutrition, 1648 mL, and less human milk, 13.8 mL/kg-day, and vitamin E, 1.4 mg/kg-day, during the second postnatal week. Human milk was a negative predictor for ROP surgery, odds ratio = 0.94. Both groups met vitamin A recommendations; however, 74% was administered via IM injections. Neither group met vitamin E recommendations.Conclusions: Human milk feeding, parenteral nutrition volume and vitamin E intake were predictors for ROP surgery. IM vitamin A injections provided the majority of vitamin A; vitamin E administration was insufficient. Improving human milk feeding rates and vitamin dosing options may affect ROP surgery rates. (C) 2010 Elsevier Ireland Ltd. All rights reserved.