Motor cortex stimulation in rats with chronic constriction injury
Motor cortex stimulation in rats with chronic constriction injury
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慢性压迫性损伤大鼠运动皮层刺激
DOI：
10.1007/s00221-007-1158-y
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发表时间：
2008
影响因子：
2
通讯作者：
R. Rokyta
中科院分区：
文献类型：
--
作者：
Š. Vaculín;M. Franěk;A. Yamamotová;R. Rokyta
运动皮层刺激（MCS）在神经病理性疼痛的治疗中发挥了重要作用。为了评价MCS在实验动物中的作用，我们将MCS应用于由左侧坐骨神经慢性压迫性损伤（CCI）诱发的神经病理性疼痛大鼠。在MCS前、MCS后即刻、MCS后1 h和MCS后1天测量双后肢的疼痛阈值。刺激的影响进行了研究方面的偏侧性（对侧和同侧MCS）和持续时间（短期10分钟和长期1小时刺激）。结果发现，在对照组大鼠中，MCS不影响热伤害性阈值。然而，在CCI动物中获得了以下结果：在短期和长期对侧MCS后，（结扎和未结扎后肢之间的缩爪潜伏期差异）显著降低;长期同侧MCS后的差异评分（与结扎后肢相关）与完整动物无显著差异;对侧短时程和同侧长时程刺激的效应均在MCS结束后1 h内消退，而对侧长时程刺激的效应在MCS结束后1 h仍保持不变，在24 h内消退。结论：MCS在实验动物中发挥与人类神经病理性疼痛相似的作用，并且这种作用可能是由两个大脑皮层引起的。
Motor cortex stimulation (MCS) has gained a significant role in treatment of neuropathic pain. In order to evaluate effect of MCS in experimental animals we applied MCS to rats with neuropathic pain, which was evoked by chronic constriction injury (CCI) to the left sciatic nerve. Pain thresholds of both hind limbs were measured before, immediately after MCS, 1 h after MCS and 1 day after MCS. Effect of the stimulation was studied with respect to laterality (contralateral and ipsilateral MCS) and duration (short-term 10-min and long-term 1-h stimulation). It was found out that in control rats MCS did not affect thermal nociceptive thresholds. However, in CCI animals following results were obtained: difference score (difference in paw withdrawal latency between ligated and non-ligated hind limb) significantly decreased after both short- and long-term contralateral MCS; the difference score after the long-term ipsilateral MCS (related to the ligated hind limb) was not significantly different from that of intact animals; the effects of the contralateral short-term and the ipsilateral long-term stimulation faded within 1 h after the end of MCS, while the effect of the contralateral long-term MCS remained 1 h after the end of the MCS and faded within 24 h. It is concluded that MCS in experimental animals exerts similar effects as in human suffering from neuropathic pain and that the effect might be evoked from both cerebral cortices.