Insulin secretion stimulating effects of mogroside V and fruit extract of luo han kuo (Siraitia grosvenori Swingle) fruit extract..
Insulin secretion stimulating effects of mogroside V and fruit extract of luo han kuo (Siraitia grosvenori Swingle) fruit extract..
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发表时间：
2009-11
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通讯作者：
Ying Zhou;Yan Zheng;J. Ebersole;Chi-fu Huang
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作者：
Ying Zhou;Yan Zheng;J. Ebersole;Chi-fu Huang
罗汉果（Siraitia grosvenori Swingle）是一种原产于中国的水果，几个世纪以来一直被用作天然甜味剂，据报道对糖尿病人群有益。然而，目前尚未有足够的研究来阐明甜味作用与可能与 LHK 水果（罗汉果果）的潜在健康益处相关的生物参数之间的关系。本研究使用体外细胞模型系统检查了 LHK 果实及其化学成分对胰岛素分泌的影响。罗汉果甙V是LHK果实中罗汉果甙中最丰富、最甜的化学成分。实验数据表明，LHK粗提取物刺激胰腺β细胞分泌胰岛素；此外，从 LHK 果实中分离出的纯罗汉果苷 V 在刺激 β 细胞分泌胰岛素方面也表现出显着的活性，这可能是 LHK 果实和果实提取物的胰岛素分泌活性的部分原因。目前的研究表明，LHK 水果/提取物有潜力成为低血糖指数的天然甜味剂，而罗汉果苷 V（可能还有其他相关的罗汉果苷）可以对刺激胰岛素分泌产生积极的健康影响。
Luo han kuo fruit (Siraitia grosvenori Swingle), a fruit native to China, has been used as a natural sweetening agent for centuries and has been reported to be beneficial for diabetic population. However, limited research has been conducted to elucidate the relationship between the sweetening action and biological parameters that may be related to potential health benefits of LHK fruit (Luo Han Kuo fruit). The present study examined the effect of LHK fruit and its chemical components on insulin secretion using an in vitro cell model system. Mogroside V is the most abundant and the sweetest chemical component among the mogrosides in LHK fruit. The experimental data demonstrated that the crude LHK extract stimulated the secretion of insulin in pancreatic beta cells; furthermore, pure mogroside V isolated from LHK fruit also exhibited a significant activity in stimulating insulin secretion by the beta cells, which could partially be responsible for the insulin secretion activity of LHK fruit and fruit extract. The current study supports that LHK fruit/extract has the potential to be natural sweetener with a low glycemic index, and that mogroside V, possible other related mogrosides, can provide a positive health impact on stimulating insulin secretion.