HIBERNOMAS ARE CHARACTERIZED BY REARRANGEMENTS OF CHROMOSOME BANDS 11Q13-21
HIBERNOMAS ARE CHARACTERIZED BY REARRANGEMENTS OF CHROMOSOME BANDS 11Q13-21
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DOI：
10.1002/ijc.2910580408
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发表时间：
1994-08-15
影响因子：
6.4
通讯作者：
MANDAHL, N
中科院分区：
文献类型：
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作者：
MERTENS, F;RYDHOLM, A;MANDAHL, N
细胞遗传学分析显示，在9例脂肪源性肿瘤（4例冬眠瘤、4例典型脂肪瘤和1例混合性粘液样和高分化脂肪肉瘤）中11q13-21存在结构重排。两个冬眠瘤和所有脂肪瘤同时表现出异常，这可归因于先前在良性脂肪组织肿瘤中发现的细胞遗传学亚群，即多余的环状染色体或6p、12q13-15或13q的重排。脂肪肉瘤的唯一异常是4向易位t(9;11;22;12)(q21;q13;q11;q13)，这种异常以前在粘液样脂肪肉瘤或高分化脂肪肉瘤中未被发现。加上我们的4例，共报告了7例细胞遗传学异常的冬眠瘤。5个肿瘤显示11q13和11q21的2重排，表明11号染色体的这一片段含有一个或多个在冬眠瘤发展中重要的基因。11q13-21的重排在典型的脂肪瘤中也很常见；共有8例11q13-21改变的典型脂肪瘤被描述，包括我们的系列病例。然而，除了1个之外，在6p， 12q13-15或13q中也发现了断点。(C) 1994 Wiley-Liss, Inc。
Cytogenetic analysis revealed structural rearrangements of 11q13-21 in 9 lipogenic tumors-4 hibernomas, 4 typical lipomas and 1 mixed myxoid and well-differentiated liposarcoma. Two hibernomas and all lipomas simultaneously showed aberrations attributable to previously recognized cytogenetic subgroups among benign adipose tissues tumors, i.e., supernumerary ring chromosomes or rearrangements of 6p, 12q13-15, or 13q. The sole anomaly in the liposarcoma was a 4-way translocation t(9;11;22;12)(q21;q13;q11;q13), an aberration that has not previously been detected in either myxoid or well-differentiated liposarcomas. Together with our 4 cases, a total of 7 cytogenetically aberrant hibernomas have been reported. Five tumors have shown rearrangements of 11q13 and 2 of 11q21, indicating that this segment of chromosome 11 harbors one or more genes of importance in hibernoma development. Rearrangements of 11q13-21 also appear to be frequent in typical lipomas; a total of 8 typical lipomas with 11q13-21 changes have been described, including those in our series. In all but 1, however, breakpoints were also found in 6p, 12q13-15, or 13q. (C) 1994 Wiley-Liss, Inc.