Nonrespiratory Comorbidities in Asthma.
Nonrespiratory Comorbidities in Asthma.
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DOI:
10.1016/j.jaip.2021.08.027
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发表时间:
2021-11
期刊:
影响因子:
--
通讯作者:
Lockey RF
中科院分区:
文献类型:
--
作者:
Cardet JC;Bulkhi AA;Lockey RF
Asthma is a chronic heterogeneous airway disease. Common comorbid conditions are often disproportionately present in severe asthma. Optimal care of patients with asthma requires the recognition and treatment of these comorbid conditions. This review outlines the pathophysiologic mechanisms between non-respiratory comorbid conditions and asthma and their effect on asthma outcomes. They include: type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease, adrenal and thyroid gland diseases, pregnancy, osteoporosis, adverse effects from medications, and mental health disorders. Studies indicate how poor glycemic control of type 2 diabetes mellitus is not only associated with greater healthcare utilization but poorer asthma outcomes. Also, a large healthcare claims database indicates that a substantial proportion of pregnant women have uncontrolled asthma and are prescribed suboptimal controller therapy. Additional data about these non-respiratory comorbidities and medications known to benefit both non-respiratory comorbidities and asthma are necessary.
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