Eosinophil responses during COVID-19 infections and coronavirus vaccination
Eosinophil responses during COVID-19 infections and coronavirus vaccination
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DOI：
10.1016/j.jaci.2020.04.021
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发表时间：
2020-07-01
影响因子：
14.2
通讯作者：
Rothenberg, Marc E.
中科院分区：
文献类型：
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作者：
Lindsley, Andrew W.;Schwartz, Justin T.;Rothenberg, Marc E.
嗜酸性粒细胞是循环和组织驻留的白细胞，在许多疾病中具有有效的促炎作用。最近，嗜酸性粒细胞已被证明具有各种其他功能，包括免疫调节和抗病毒活性。嗜酸性粒细胞水平在许多临床环境中差异很大，特别是在嗜酸性粒细胞靶向治疗之后，现在可以选择性地消耗这些细胞。有一些与 2019 年冠状病毒病 (COVID-19) 相关的关键问题涉及嗜酸性粒细胞，其答案会影响建议的预防和护理。首先，患有嗜酸性粒细胞增多相关疾病的患者的 COVID-19 病程是否发生改变？其次，嗜酸性粒细胞减少症（现在由生物药物有意诱导）患者是否具有独特的COVID-19易感性和/或病程？这是一个特别相关的问题，因为嗜酸性粒细胞减少症与严重急性呼吸综合征冠状病毒 2（COVID-19 的病原体）感染期间的急性呼吸系统恶化有关。第三，嗜酸性粒细胞是否会导致 COVID-19 期间诱发的肺部病理？它们是否会有助于与新兴的 COVID-19 疫苗相关的免疫增强？在此，我们在新出现的 COVID-19 大流行期间解决这些及时的问题和项目考虑因素。
Eosinophils are circulating and tissue-resident leukocytes that have potent proinflammatory effects in a number of diseases. Recently, eosinophils have been shown to have various other functions, including immunoregulation and antiviral activity. Eosinophil levels vary dramatically in a number of clinical settings, especially following eosinophil-targeted therapy, which is now available to selectively deplete these cells. There are key coronavirus disease 2019 (COVID-19)-related questions concerning eosinophils whose answers affect recommended prevention and care. First, do patients with eosinophiliaassociated diseases have an altered course of COVID-19? Second, do patients with eosinopenia (now intentionally induced by biological drugs) have unique COVID-19 susceptibility and/or disease course? This is a particularly relevant question because eosinopenia is associated with acute respiratory deterioration during infection with the severe acute respiratory syndrome coronavirus 2, the causative agent of COVID-19. Third, do eosinophils contribute to the lung pathology induced during COVID-19 and will they contribute to immunopotentiation potentially associated with emerging COVID-19 vaccines? Herein, we address these timely questions and project considerations during the emerging COVID-19 pandemic.