Essential function of oncostatin M in nociceptive neurons of dorsal root ganglia
Essential function of oncostatin M in nociceptive neurons of dorsal root ganglia
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DOI：
10.1523/jneurosci.4975-03.2004
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发表时间：
2004-02-25
影响因子：
5.3
通讯作者：
Senba, E
中科院分区：
文献类型：
--
作者：
Morikawa, Y;Tamura, S;Senba, E
肿瘤抑制素M（OSM）是白细胞介素6家族的一员，我们以前曾报道过OSM受体β亚单位（OSMR）在成年三叉神经节、背根神经节和围生儿舌下神经核的部分神经元中表达。在本研究中，我们研究了OSM缺陷小鼠背根节OSMR阳性神经元的发育。原位杂交结果显示，OSMR阳性神经元在出生后0天（P0）开始出现，并在P14时达到成年水平。在OSM缺陷小鼠的DRG中，香草酸受体1（VR 1）和P2 X3阳性的小型神经元显著减少。此外，OSMR阳性神经元减少，导致VR 1/P2 X3/OSMR三重阳性神经元的数量减少。在急性热、机械、化学和内脏疼痛模型中，OSM缺陷小鼠显示出显著降低的伤害性反应。因此，OSM在DRG中伤害感受神经元亚型的发育中起着至关重要的作用。
Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines, and we have reported previously that the murine OSM receptor beta subunit (OSMR) was expressed in some neurons in the adult trigeminal and dorsal root ganglia (DRGs) and in the perineonatal hypoglossal nucleus. In the present study, we investigated the development of OSMR-positive neurons of DRGs in OSM-deficient mice. In situ hybridization revealed that OSMR-positive neurons in DRGs began to appear at postnatal day 0 (P0) and reached the adult level at P14. In the DRGs of the OSM-deficient mice, vanilloid receptor 1 (VR1)- and P2X3-positive small-sized neurons were significantly decreased. In addition, OSMR-positive neurons decreased, resulting in the reduced number of VR1/P2X3/OSMR-triple positive neurons. OSM-deficient mice displayed significantly reduced noxious responses in models of acute thermal, mechanical, chemical, and visceral pain. Thus, OSM plays an essential role in the development of a subtype of nociceptive neurons in the DRGs.