Saccadic system plasticity mechanisms in Parkinson disease patients
Saccadic system plasticity mechanisms in Parkinson disease patients
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DOI：
10.1016/j.jfo.2011.05.009
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发表时间：
2012-04-01
影响因子：
1.2
通讯作者：
Tilikete, C.
中科院分区：
文献类型：
--
作者：
Abouaf, L.;Panouilleres, M.;Tilikete, C.
导论. - 随意或反应性扫视在快速眼球运动中占主导地位。他们的目标是保持对环境的积极和最佳的视觉感知。扫视一旦启动就无法引导。眼球可塑性，或扫视适应，仍然是部分未知的，特别是基底神经节所发挥的作用。新的神经眼科康复技术需要了解神经生理学基础，并证明参与这种可塑性的神经元结构。- 本研究评估了特发性帕金森病患者的反应性扫视适应，作为基底神经节功能障碍的模型。我们预测，扫视适应将保留在这种病理。- 研究纳入了5例轻度特发性偏侧帕金森病患者，以及4例年龄匹配的对照组。采用双步目标模式研究了OFF-Dopa治疗组和对照组的反应性扫视适应。- 组间分析表明，患者的适应水平低于对照组（P < 0.05）。个别地，两名患者不适应双侧扫视和同侧（相比帕金森运动临床综合征）扫视。另外两名患者适应了两侧，但与对照组相比，对侧扫视有缺陷。- 这些初步结果表明基底神经节参与反应性扫视适应，这仍有待澄清。(c)2011年Elsevier Masson SAS。All rights reserved.
Introduction. - Voluntary or reactive saccades predominate in rapid eye movements. Their goal is to preserve an active and optimal visual perception of the environment. Saccades cannot be guided once launched. Oculomotor plasticity, or saccadic adaptation, is still partially unknown, in particular the role played by the basal ganglia. New neuro-ophthalmological rehabilitation techniques require understanding the neurophysiological basis and demonstrating the neuronal structures involved in this plasticity.Objectives. - This study assessed the reactive saccade adaptation in patients with idiopathic Parkinson disease, as a model of basal ganglia dysfunction. We predicted that saccadic adaptation would be preserved in this pathology.Patients and methods. - Five patients with mild idiopathic hemi-Parkinson disease were included, as well as four age-matched controls. Reactive saccade adaptation was studied using the double-step target paradigm, in patients with OFF-Dopa treatment and in controls.Results. - Group analysis demonstrated that patients had a lower level of adaptation than the controls (p < 0.05). Individually, two patients did not adapt for bilateral saccades and one for ipsilateral (compared to Parkinson motor clinical syndrome) saccades. Two additional patients adapted on both sides but with a deficit in contralateral saccades when compared to the control group.Discussion. - These preliminary results suggest basal ganglia involvement in reactive saccadic adaptation, which remains to be clarified. (c) 2011 Elsevier Masson SAS. All rights reserved.