Gastrointestinal symptoms before and during menses in healthy women
Gastrointestinal symptoms before and during menses in healthy women
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DOI：
10.1186/1472-6874-14-14
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发表时间：
2014-01-22
影响因子：
2.5
通讯作者：
Targownik, Laura E.
中科院分区：
文献类型：
--
作者：
Bernstein, Matthew T.;Graff, Lesley A.;Targownik, Laura E.
背景：关于月经期妇女报告的胃肠道（GI）投诉的程度知之甚少。我们的目的是描述胃肠道症状，发生在月经前和月经期间的健康女性，并具体评估周围menuses.Methods的情绪症状胃肠道症状的关系：我们招募了健康，绝经前的成年女性没有迹象表明胃肠道，妇科，或精神疾病谁是参加妇科门诊的妇女保健。他们完成了一项调查，询问月经史和胃肠道和情绪症状的存在。我们比较了原发性胃肠道症状的患病率，结果：在156名受访者中，73%的人在月经前或月经期间经历了至少一种主要胃肠道症状，包括腹痛、腹泻、便秘、恶心、呕吐。（术前58%;术中55%）和腹泻（术前24%;术中28%）是最常见的。与没有情绪症状的人相比，那些经历过任何情绪症状的人更有可能报告多种（2种或更多种）原发性GI症状，包括产前（抑郁p = 0.006;焦虑p = 0.014）和月经期间（抑郁p < 0.001;焦虑p = 0.008）。疲劳也很常见（术前53%;术中49%），并且在两个月经周期阶段与多种GI症状显著相关（术前p < 0.001;术中p = 0.01）。结论：与GI症状一起发生的情绪症状在围月经期很常见，因此可能反映了与大脑，肠道和激素通路交叉的共同潜在过程。
Background: Little is known as to the extent gastrointestinal (GI) complaints are reported by women around menses. We aimed to describe GI symptoms that occurred premenstrually and during menses in healthy women, and to specifically assess the relationship of emotional symptoms to GI symptoms around menses.Methods: We recruited healthy, premenopausal adult women with no indication of GI, gynecologic, or psychiatric disease who were attending an outpatient gynecology clinic for well-woman care. They completed a survey that queried menstrual histories and the presence of GI and emotional symptoms. We compared the prevalence of primary GI symptoms (abdominal pain, diarrhea, constipation, nausea, vomiting), as well as pelvic pain and bloating, in the 5 days prResults: Of 156 respondents, 73% experienced at least one of the primary GI symptoms either pre- or during menses, with abdominal pain (58% pre; 55% during) and diarrhea (24% pre; 28% during) being the most common. Those experiencing any emotional symptoms versus those without were more likely to report multiple (2 or more) primary GI symptoms, both premenstrually (depressed p = 0.006; anxiety p = 0.014) and during menses (depressed p < 0.001; anxiety p = 0.008). Fatigue was also very common (53% pre; 49% during), and was significantly associated with multiple GI symptoms in both menstrual cycle phases (pre p < 0.001; during p = 0.01).Conclusions: Emotional symptoms occurring in conjunction with GI symptoms are common perimenstrually, and as such may reflect shared underlying processes that intersect brain, gut, and hormonal pathways.