The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review.
The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review.
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DOI：
10.3389/fendo.2016.00171
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发表时间：
2016
影响因子：
5.2
通讯作者：
Bunnell BA
中科院分区：
文献类型：
--
作者：
Bateman ME;Strong AL;McLachlan JA;Burow ME;Bunnell BA
内分泌干扰化学品（EDCs）在环境中普遍存在，流行病学研究表明，人类暴露与肥胖和糖尿病等慢性疾病有关。体外实验进一步证明，EDC促进间充质干细胞（MSC）的变化，导致成脂分化增加、成骨分化减少、促炎细胞因子活化、氧化应激增加和表观遗传变化。研究还显示了MSC的营养因子产生、分化能力和免疫调节能力的改变，这对目前探索MSC用于组织工程和再生医学应用以及治疗炎症性疾病的研究具有重要意义。因此，在确定MSC的潜在治疗用途时，考虑EDC对MSC的影响是至关重要的，因为增加对EDC的暴露可能导致MSC在治疗上不那么有效。这篇综述的重点是内分泌干扰物的成脂和成骨分化的影响，因为这些是最相关的组织工程，再生医学和炎症条件的MSC的治疗用途。本文综述了内分泌干扰物（包括有机磷酸酯、增塑剂、工业表面活性剂、冷却剂和润滑剂）对MSC生物学的影响。
Endocrine-disrupting chemicals (EDCs) are prevalent in the environment, and epidemiologic studies have suggested that human exposure is linked to chronic diseases, such as obesity and diabetes. In vitro experiments have further demonstrated that EDCs promote changes in mesenchymal stem cells (MSCs), leading to increases in adipogenic differentiation, decreases in osteogenic differentiation, activation of pro-inflammatory cytokines, increases in oxidative stress, and epigenetic changes. Studies have also shown alteration in trophic factor production, differentiation ability, and immunomodulatory capacity of MSCs, which have significant implications to the current studies exploring MSCs for tissue engineering and regenerative medicine applications and the treatment of inflammatory conditions. Thus, the consideration of the effects of EDCs on MSCs is vital when determining potential therapeutic uses of MSCs, as increased exposure to EDCs may cause MSCs to be less effective therapeutically. This review focuses on the adipogenic and osteogenic differentiation effects of EDCs as these are most relevant to the therapeutic uses of MSCs in tissue engineering, regenerative medicine, and inflammatory conditions. This review will highlight the effects of EDCs, including organophosphates, plasticizers, industrial surfactants, coolants, and lubricants, on MSC biology.
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影响因子：
3.7
作者：
Croes M;Oner FC;Kruyt MC;Blokhuis TJ;Bastian O;Dhert WJ;Alblas J
通讯作者：
Alblas J
影响因子：
3.7
作者：
Ariemma F;D'Esposito V;Liguoro D;Oriente F;Cabaro S;Liotti A;Cimmino I;Longo M;Beguinot F;Formisano P;Valentino R
通讯作者：
Valentino R
影响因子：
--
作者：
Chiellini, Chiara;Cochet, Olivia;Amri, Ez-Zoubir
通讯作者：
Amri, Ez-Zoubir
影响因子：
2.7
作者：
De Felice B;Manfellotto F;Palumbo A;Troisi J;Zullo F;Di Carlo C;Di Spiezio Sardo A;De Stefano N;Ferbo U;Guida M;Guida M
通讯作者：
Guida M
影响因子：
10.4
作者：
Baker NA;Karounos M;English V;Fang J;Wei Y;Stromberg A;Sunkara M;Morris AJ;Swanson HI;Cassis LA
通讯作者：
Cassis LA