Genetic analysis of an ADRV-N-like novel rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh
Genetic analysis of an ADRV-N-like novel rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh
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DOI：
10.1007/s00705-006-0831-y
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Naik, T. N.
中科院分区：
文献类型：
--
作者：
Alam, M. M.;Kobayashi, N.;Naik, T. N.
2002年4月，孟加拉国一名65岁腹泻患者的粪便标本中检测到了一种不寻常的人类轮状病毒株B219。对B219株五个基因的克隆和序列分析表明，该病毒在基因上与引起中国成人腹泻暴发的ADRV-N株密切相关，但与已知引起人类腹泻疾病的A、B和C组轮状病毒不同。因此，轮状病毒株B219和ADRV-N被认为属于新的人类轮状病毒群，并且ADRV-N样的新型人类轮状病毒被认为分布于更广泛的地理区域。
An unusual human rotavirus strain B219 was detected in a stool specimen from a 65-year old patient with diarrhea in Bangladesh during April 2002. Cloning and sequence analysis of five genes of the B219 strain indicated that this virus is genetically closely related to the ADRV-N strain, which caused an adult diarrhea outbreak in China, but distinct from groups A, B, and C rotaviruses known to cause diarrheal diseases in humans. Accordingly, rotavirus strains B219 and ADRV-N were considered to belong to a novel group of human rotavirus, and the ADRV-N-like novel human rotaviruses were suggested to be distributed to a geographically wider area.