Association of KIBRA and memory
Association of KIBRA and memory
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DOI：
10.1016/j.neulet.2009.04.050
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发表时间：
2009-07-24
影响因子：
2.5
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Bates, Timothy C.;Price, Jackie F.;Deary, Ian J.
我们报告了两个老年人样本中Kibra与记忆的关联，两个样本都对语义无关的单词刺激进行了记忆评估(Rey听觉单词学习测试，n=2091)。或语义相关材料的测量(散文段落回忆的WAIS逻辑记忆测试，n=542)。SNP rs17070145与语义无关项目的延迟回忆有关，但与这些刺激的即时回忆无关，也与语义相关材料的即时或延迟回忆无关。结果表明，Kibra基因内含子9中的T>；C替换在情景记忆的一个组成部分中发挥了作用，该记忆参与长期储存，但独立于与即时回忆共享的过程，如涉及习得和复述或过程的复习。(C)2009年，爱思唯尔爱尔兰有限公司出版。
We report on the association of KIBRA with memory in two samples of older individuals assessed on either memory for semantically unrelated word stimuli (Rey Auditory Verbal Learning Test, n = 2091). or a measure of semantically related material (the WAIS Logical Memory Test of prose-passage recall, n = 542). SNP rs17070145 was associated with delayed recall of semantically unrelated items, but not with immediate recall for these stimuli, nor with either immediate or delayed recall for semantically related material. The pattern of results suggests a role for the T -> C substitution in intron 9 of KIBRA in a component of episodic memory involved in long-term storage but independent of processes shared with immediate recall such as rehearsal involved in acquisition and rehearsal or processes. (C) 2009 Published by Elsevier Ireland Ltd.