Effect of bariatric surgery on circulating chemerin levels
Effect of bariatric surgery on circulating chemerin levels
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DOI：
10.1111/j.1365-2362.2010.02255.x
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发表时间：
2010-03-01
影响因子：
5.5
通讯作者：
Kaser, S.
中科院分区：
文献类型：
--
作者：
Ress, C.;Tschoner, A.;Kaser, S.
研究背景肥胖症的亚临床炎症是导致肥胖症相关疾病的关键因素。我们着手研究体重明显减轻对循环chemerin水平的影响，也通过旁分泌和自分泌机制影响脂肪细胞功能的化学引诱蛋白。对两名接受减肥手术的肥胖患者在胃束带或胃旁路手术前和手术后平均18个月进行了测试。结果减肥手术后体重明显减轻，同时参数也有所改善脂联素水平升高。减肥手术后，趋化剂chemerin从175中心点91 +/- 24中心点50显著降低至145中心点53 +/- 26中心点44 ng mL-1（P < 0中心点01）。同时，作为亚临床炎症标志物的hs-CRP在体重减轻后显著降低（P < 0中心点01）.结论我们假设体重减轻引起的循环chemerin的减少可能与其它因素一起与脂肪组织中巨噬细胞募集的减少和亚临床炎症的减少有关，这也可以部分解释减肥对肥胖受试者的长期有益影响。
P>BackgroundSubclinical inflammation in obesity is critical for development of several obesity-associated disorders. We set out to investigate the effect of pronounced weight loss on circulating chemerin levels, a chemoattractant protein that also influences adipose cell function by paracrine and autocrine mechanisms.Material and methodsThirty-two obese patients undergoing bariatric surgery were tested before and on an average of 18 months after gastric banding or gastric bypass surgery.ResultsPronounced weight loss after bariatric surgery was accompanied by improvements in parameters of lipid and glucose metabolism and increased adiponectin levels. Chemoattractant chemerin significantly decreased from 175 center dot 91 +/- 24 center dot 50 to 145 center dot 53 +/- 26 center dot 44 ng mL-1 after bariatric surgery (P < 0 center dot 01). Concomitantly, hs-CRP as a marker of subclinical inflammation was significantly reduced after weight reduction (P < 0 center dot 01).ConclusionsWe hypothesize that weight-loss induced reduction in circulating chemerin might in conjunction with other factors be associated with diminished recruitment of macrophages in adipose tissue and reduction of subclinical inflammation, which again could partly explain beneficial long-term effects of weight reduction in obese subjects.