Prefrontal cortex projections to the nucleus reuniens suppress freezing following two-way signaled avoidance training.
Prefrontal cortex projections to the nucleus reuniens suppress freezing following two-way signaled avoidance training.
复制标题
前额皮质向团聚核的投射抑制了双向信号回避训练后的冻结。
DOI：
10.1101/lm.050377.119
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Moscarello,JustinM
中科院分区：
文献类型：
--
作者：
Moscarello,JustinM
信号主动回避（SAA）行为需要抑制与回避反应相冲突的防御反应，如冻结。这种抑制过程的神经机制还不清楚。在这里，我们证明，腹内侧前额叶皮质投射到丘脑的核reuniens招募SAA训练后，以抑制大鼠冻结。这种投射可能是抑制先天防御反应的一个重要的共同途径，这些防御反应会干扰主动行为，从而促进适应性应对。
Signaled active avoidance (SAA) behavior requires the suppression of defensive reactions, such as freezing, that conflict with the avoidance response. The neural mechanisms of this inhibitory process are not well understood. Here, we demonstrate that ventromedial prefrontal cortex projections to the nucleus reuniens of the thalamus are recruited following SAA training to suppress freezing in rats. This projection may serve as a crucial common pathway for the inhibition of innate defensive reactions that interfere with proactive behavior, thus facilitating adaptive coping.