Increased expression of vascular endothelial growth factor in hepatocellular carcinoma after transcatheter arterial chemoembolization
Increased expression of vascular endothelial growth factor in hepatocellular carcinoma after transcatheter arterial chemoembolization
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DOI：
10.1080/02841850801958890
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发表时间：
2008-01-01
期刊：
影响因子：
1.3
通讯作者：
Cao, G. W.
中科院分区：
文献类型：
--
作者：
Wang, B.;Xu, H.;Cao, G. W.
背景资料：经导管动脉化疗栓塞（TACE）后残留的活肝细胞癌（HCC）组织的生物学行为变化尚不清楚。有研究表明TACE可抑制肿瘤血管生成并诱导肿瘤细胞凋亡，但也有研究发现TACE可刺激肿瘤血管生成，从而在一定程度上增强肿瘤细胞的增殖活性。目的：探讨肝细胞癌（HCC）TACE术后残留癌组织中微血管密度（MVD）和血管内皮生长因子（VEGF）的表达。研究了63例组织病理学诊断患者的肿瘤标本：42例为对照组（仅接受手术治疗），21例为TACE组（手术切除前接受1-2次TACE治疗）。结果：对照组和TACE组的MVD分别为51.69 ± 18.17和58.57 ± 15.75;两组比较差异无统计学意义（t = 1.48，P > 0.05）。对照组和TACE组的微血管直径分别为17.62 ± 10.54 mm和15.79 ± 7.65 mm，两组间差异无统计学意义（t = 0.71，P > 0.05）。TACE组中VEGF阳性细胞的数量，即，243.66 ± 88.88，高于对照组，即，138.26 ± 65.24（t = 5.34，P
Background: Changes in the biological behavior of residual viable hepatocellular carcinoma (HCC) tissue after transcatheter arterial chemoembolization (TACE) remain unclear. Several studies have reported that TACE inhibits tumor angiogenesis and induces tumor cell apoptosis, while other studies have found that TACE stimulates tumor angiogenesis and thus increases the proliferative activity of the tumor cells to some degree.Purpose: To investigate the intratumoral microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in residual surviving cancerous tissue after TACE in HCC.Material and Methods: Tumor specimens from 63 histopathologically diagnosed patients were studied: 42 comprising the control group (treated by surgery alone) and 21 comprising the TACE group (those treated by TACE 1-2 times prior to surgical resection). The number of VEGF-positive cells, MVD, and microvessel diameter were measured.Results: The MVD was 51.69 +/- 18.17 and 58.57 +/- 15.75 in the control and TACE groups, respectively. There was no significant difference between the two groups (t = 1.48, P > 0.05). The microvessel diameter was 17.62 +/- 10.54 mm and 15.79 +/- 7.65 mm in the control and TACE groups, respectively, indicating no significant difference between the two groups (t = 0.71, P > 0.05). The number of VEGF-positive cells in the TACE group, i.e., 243.66 +/- 88.88, was higher than that in the control group, i.e., 138.26 +/- 65.24 (t = 5.34, P